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AB246896

Anti-CCDC67 antibody

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Rabbit Polyclonal CCDC67 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human DEUP1 aa 100-250.

View Alternative Names

CCDC67, DEUP1, Deuterosome assembly protein 1, Coiled-coil domain-containing protein 67

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC67 antibody (AB246896)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC67 antibody (AB246896)

Paraffin-embedded human testis tissue stained for CCDC67 using ab246896 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DEUP1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q05D60

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Cynomolgus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CCDC67 protein also known as coiled-coil domain-containing protein 67 is involved in cellular structural integrity and regulation. This protein has a molecular mass of approximately 58 kDa. Researchers found CCDC67 expression occurs in various tissues with notable expression in testis and epithelial tissues. The structural element it provides through the coiled-coil domains likely aids in maintaining cellular architecture.
Biological function summary

The coiled-coil domains allow CCDC67 to participate in multiprotein complexes that play roles in cell division and intracellular transport. This protein interacts with other structural proteins contributing to maintaining cell morphology and stability. By forming these complexes CCDC67 supports communication and transport between cellular components essential for normal cellular functions.

Pathways

CCDC67 participates actively in the signaling pathways related to cell cycle regulation and cytoskeleton arrangements. This protein associates with the microtubule network linking to pathways involving cytoskeletal organization and mitotic progression. CCDC67's interactions with proteins like α-tubulin and β-tubulin highlight its role in supporting these pathways ensuring cellular processes function efficiently.

Researchers found alterations in the expression of CCDC67 linked to cancer especially affecting pathways altering cellular architecture and division. Its relationship with well-known tumor suppressor proteins like p53 suggests its potential role in tumorigenesis. CCDC67 alterations also correlate with congenital disorders affecting cellular structure where its interaction with cytoskeletal proteins becomes disrupted leading to disease phenotypes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).
See full target information DEUP1
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