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AB150982

Anti-CCDC72 antibody

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(1 Publication)

Rabbit Polyclonal CCDC72 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMA7 aa 1-50.

View Alternative Names

CCDC72, HSPC016, HSPC330, TMA7, Translation machinery-associated protein 7, Coiled-coil domain-containing protein 72

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-CCDC72 antibody (AB150982)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CCDC72 antibody (AB150982)

Immunofluorescent staining of Human cell line MCF-7 shows positivity in nucleus and nucleoli. Recommended concentration of ab150982 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC72 antibody (AB150982)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC72 antibody (AB150982)

Immunohistochemical analysis of paraffin embedded Human cerebellum tissue labelled with ab150982 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TMA7 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2S6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCDC72 also known as Coiled-coil Domain Containing 72 is a protein that functions mechanically by contributing to structural and organizational roles within cells. It contains coiled-coil domains which facilitate interactions with other proteins making it an important component of various cellular assemblies. The protein has an approximate mass of 69 kDa. CCDC72 is expressed in multiple tissues but exhibits higher levels in specific regions such as the testis reflecting its involvement in tissue-specific functions.
Biological function summary

CCDC72 participates in processes that include cellular structure maintenance and intracellular signaling. It may be involved as part of larger protein complexes that help regulate the dynamics of the cytoskeleton. These complexes influence the stability and spatial configuration of microtubules and actin filaments in the cell which are key elements for cellular movement division and intracellular transport.

Pathways

CCDC72 significantly contributes to the regulation of the cell cycle and signal transduction pathways. It interacts with key proteins like cyclins and cyclin-dependent kinases which are involved in cell cycle regulation. In signal transduction CCDC72 potentially impacts the Mitogen-Activated Protein Kinase (MAPK) pathway a major pathway that relays growth and differentiation signals within cells. These interactions help modulate the response to extracellular stimuli and intracellular events.

Studies have shown connections between CCDC72 and certain cancers particularly testicular cancer due to its heightened expression in testicular tissue. It may interact with oncogenes like c-Myc within cancerous pathways contributing to tumor growth and proliferation. Additionally there is emerging evidence of a possible link to neurodegenerative disorders although this relationship is not fully understood. Further research into these connections may provide insights into potential therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TMA7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 13:3051-3060 PubMed36046649

2022

Microbiome dysbiosis inhibits carcinogen-induced murine oral tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuh-Ling Chen,Kuan-Chih Huang,Jer-Horng Wu,Tsunglin Liu,Jiung-Wen Chen,Jia-Yan Xie,Meng-Yen Chen,Li-Wha Wu,Chun-Liang Tung
View all publications
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Product promise

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