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AB173457

Anti-CCDC88B antibody

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(1 Publication)

Mouse Polyclonal CCDC88B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CCDC88B aa 450 to C-terminus.

View Alternative Names

BRLZ, CCDC88B, Coiled-coil domain-containing protein 88B, Brain leucine zipper domain-containing protein, Gipie, Hook-related protein 3, HkRP3

1 Images
Western blot - Anti-CCDC88B antibody (AB173457)
  • WB

Supplier Data

Western blot - Anti-CCDC88B antibody (AB173457)

All lanes:

Western blot - Anti-CCDC88B antibody (ab173457) at 1 µg/mL

Lane 1:

CCDC88B transfected 293T cell line lysate at 15 µL

Lane 2:

Non-transfected 293T cell line lysate at 15 µL

Secondary

All lanes:

Goat anti-Mouse IgG at 1/2500 dilution

Predicted band size: 164 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human CCDC88B aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

A6NC98

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CCDC88B protein also known by the alternate name "GIV" mechanically functions as a coiled-coil domain-containing protein. It has a molecular mass of approximately 164 kDa. This protein is mainly expressed in immune cells such as T cells and dendritic cells. CCDC88B plays a role in the intracellular signaling processes which are important for the regulation and expression of genes within these cells.
Biological function summary

The CCDC88B protein contributes to the immune response by modulating the signaling pathways that activate immune cells. It does not exist as a part of a larger protein complex but influences the activity of signaling complexes. The modulation by CCDC88B enhances immune cell survival growth and differentiation. Through its interaction with other signaling proteins it ensures an appropriate immune response to various stimuli.

Pathways

The CCDC88B protein acts within the Wnt signaling and NF-kB pathways. In the Wnt signaling pathway CCDC88B affects the regulation of gene expression cell behavior and immune cell responses. It interacts with other proteins in these pathways such as Dishevelled (DVL) in the Wnt pathway influencing the cascade of signaling events. By serving a critical function here CCDC88B helps in controlling cellular dynamics and immune reactions.

CCDC88B shows a notable connection with autoimmune disorders and inflammatory diseases. Dysregulation of CCDC88B expression or function can contribute to conditions like multiple sclerosis and rheumatoid arthritis. The protein's interaction with RelB a member of the NF-kB signaling pathway can have implications in these diseases affecting the immune system's balance. Certain therapeutic approaches explore targeting CCDC88B to restore immune function and ameliorate such autoimmune and inflammatory conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed : 25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed : 21289099).
See full target information CCDC88B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2402509 PubMed38590132

2024

Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification.

Applications

Unspecified application

Species

Unspecified reactive species

Bairen Pang,Qi Wang,Haotian Chen,Zhihan Liu,Meng Han,Jie Gong,Liang Yue,Xuan Ding,Suying Wang,Zejun Yan,Yingzhi Chen,David Malouf,Joseph Bucci,Tiannan Guo,Cheng Zhou,Junhui Jiang,Yong Li
View all publications
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Product promise

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