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AB235780

Anti-CCDC89 antibody

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(2 Publications)

Rabbit Polyclonal CCDC89 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CCDC89 aa 1-200.

View Alternative Names

BOIP, CCDC89, Coiled-coil domain-containing protein 89, Bc8 orange-interacting protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC89 antibody (AB235780)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC89 antibody (AB235780)

Paraffin-embedded human pancreas tissue stained for CCDC89 using ab235780 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC89 antibody (AB235780)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC89 antibody (AB235780)

Paraffin-embedded human skin tissue stained for CCDC89 using ab235780 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-CCDC89 antibody (AB235780)
  • WB

Supplier Data

Western blot - Anti-CCDC89 antibody (AB235780)

All lanes:

Western blot - Anti-CCDC89 antibody (ab235780) at 1/1000 dilution

All lanes:

Mouse kidney tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 44 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human CCDC89 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q8N998

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCDC89 also known as coiled-coil domain containing 89 is a protein with a molecular mass of approximately 33 kDa. It is expressed in various tissues including heart kidney and liver. The protein structure features distinctive coiled-coil domains enabling it to perform mechanical roles in cellular environments. These domains typically facilitate protein-protein interactions important for the wide range of cellular activities that CCDC89 might be involved in.
Biological function summary

CCDC89 participates in processes that influence cell structure and function. It does not act in isolation; instead it associates with other proteins to form complexes that regulate these cellular processes. Scientific evidence suggests its role in cytoskeletal organization making it an important player in maintaining cellular integrity and function. The protein's interaction with other cytoskeletal components underlines its influence in the biological processes occurring within the cell.

Pathways

CCDC89 is integrated into the cytoskeletal signaling pathway powering coordinated cellular dynamics. It interacts closely with proteins such as tubulin which is central to microtubule formation and actin which is essential for the formation of various filament structures. By participating in these pathways CCDC89 contributes to the regulation of the cytoskeleton impacting cellular functions like division movement and shape maintenance.

Disruptions involving CCDC89 have been linked to cardiac hypertrophy and polycystic kidney disease. Research indicates that alterations in CCDC89 expression or function can lead to imbalances in cytoskeletal dynamics resulting in pathological states. In cardiac hypertrophy abnormal signaling can occur alongside proteins like titin contributing to maladaptive heart muscle growth. Similarly in polycystic kidney disease its interactions with polycystin proteins might influence abnormal cell proliferation that characterizes this disorder.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CCDC89
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:405 PubMed40393967

2025

Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxia Zhou,Guifang Wang,Lingling Liu,Lingyu Song,Laying Hu,Lu Liu,Lifen Xu,Tuanlao Wang,Lirong Liu,Yuanyuan Wang,Tian Zhang,Bing Guo

OncoTargets and therapy 14:3721-3728 PubMed34140780

2021

G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yunfen Li,Zhengting Chen,Ke Cao,Lan Zhang,Yuhui Ma,Shuhui Yu,Hanyu Jin,Xiaoling Liu,Wenhui Li
View all publications
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Product promise

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