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AB75153

Anti-CCK1-R antibody

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(3 Publications)

Rabbit Polyclonal CCK1-R antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CCKAR.

View Alternative Names

CCKRA, CCKAR, Cholecystokinin receptor type A, CCK-A receptor, CCK-AR, Cholecystokinin-1 receptor, CCK1-R

1 Images
Western blot - Anti-CCK1-R antibody (AB75153)
  • WB

Unknown

Western blot - Anti-CCK1-R antibody (AB75153)

All lanes:

Western blot - Anti-CCK1-R antibody (ab75153) at 1/500 dilution

Lane 1:

Extracts from HUVEC cells at 5 µg

Lane 2:

Extracts from HUVEC cells at 5 µg with immunising peptide

Predicted band size: 48 kDa

Observed band size: 45 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CCKAR. The exact immunogen used to generate this antibody is proprietary information.

P32238

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Biochemicals

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCK1-R also known as the Cholecystokinin receptor is a G-protein coupled receptor. It specifically binds to the gastrointestinal hormone cholecystokinin and is involved in regulating digestive processes. The receptor is expressed in various tissues including the pancreas and small intestine and plays a significant role in facilitating digestive enzyme secretion and bile acid release. CCK1-R has a molecular mass of approximately 45 kDa. The receptor also serves as an important target for the development of CCK antagonists such as lorglumide which can be used to modify its activity.
Biological function summary

The cholecystokinin receptor helps regulate satiety and digestive enzyme secretion. It is not typically part of a larger protein complex. The binding of cholecystokinin to CCK1-R stimulates pancreatic enzyme secretion gallbladder contraction and gastric emptying inhibition. This receptor also plays a role in the modulation of food intake and energy balance mediated through its signaling pathways.

Pathways

The CCK receptor plays an important role within the digestive system's gastrointestinal hormone signaling pathway and the central nervous system's appetite regulation pathway. It interacts with various proteins including the MAP kinase pathway components to mediate physiological responses. Additionally CCK1-R is closely linked with proteins involved in the gallbladder contraction such as motilin which further highlights its contribution to digestive processes.

CCK1-R is associated with obesity and pancreatic disorders. Altered expression or function of this receptor can contribute to metabolic imbalances leading to obesity due to disrupted satiety signaling. In the context of pancreatic disorders CCK1-R is linked to pancreatitis where excessive pancreatic enzyme secretion leads to inflammation. The receptor interacts with proteins such as trypsinogen linking its role in disease progression and highlighting its significance as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
See full target information CCKAR
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 22:823 PubMed34131446

2021

Changes in the interstitial cells of Cajal in the gallbladder of guinea pigs fed a lithogenic diet.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Huang,Chao Ding,Xinmin Si

Bioscience reports 38: PubMed30361293

2018

Inhibitory effect of high leucine concentration on α-amylase secretion by pancreatic acinar cells: possible key factor of proteasome.

Applications

Unspecified application

Species

Unspecified reactive species

Long Guo,Baolong Liu,Chen Zheng,Hanxun Bai,Hao Ren,Junhu Yao,Xiurong Xu

Endokrynologia Polska 66:334-41 PubMed26323471

2015

Changes in ghrelin, CCK, GLP-1, and peroxisome proliferator-activated receptors in a hypoxia-induced anorexia rat model.

Applications

Unspecified application

Species

Unspecified reactive species

Arul Joseph Duraisamy,Susovan Bayen,Supriya Saini,Alpesh Kumar Sharma,Praveen Vats,Shashi Bala Singh
View all publications
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Product promise

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