Rabbit Polyclonal CCK2-R antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CCKBR aa 1-100.
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Publications
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- Irish journal of medical science 186:883-8882017CCK1 receptor is involved in the regulation of protein lysine acetylation in GBC-SD cells and gallbladder carcinoma.
- Reproduction (Cambridge, England) 150:257-682015Cholecystokinin receptors regulate sperm protein tyrosine phosphorylation via uptake of HCO3-.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuchuan Zhou et. al.PubMed 26175429
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human CCKBR aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link P32239
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/2000.00000 - 1/5000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/150.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
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Target data
Function
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
Alternative names
CCKRB, CCKBR, Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R
Recommended products
Rabbit Polyclonal CCK2-R antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CCKBR aa 1-100.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human CCKBR aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link P32239
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CCK2 receptors also known as cholecystokinin B receptors play important roles in the body. These receptors are part of the G protein-coupled receptor family. They have a molecular mass of approximately 48 kDa. CCK2 receptors mainly express in the brain and gastric mucosa. In the brain they regulate neurotransmission while in the stomach they influence gastric acid secretion.
- Biological function summary
CCK2 receptors interact with cholecystokinin and gastrin hormones. They are essential components of signaling complexes that mediate their effects. Interaction with these hormones leads to increased cellular calcium levels. This receptor also plays a role in modulating anxiety and pain perception in addition to its role in digestive processes.
- Pathways
CCK2 receptors are key in the gastrin signaling pathway and influence the phosphoinositide pathway. These pathways involve interaction with other proteins like CCK1 receptors and tyrosine kinases. The interplay with these pathways contributes to the activation of intracellular signaling cascades that affect cell growth and digestive enzyme secretion.
- Associated diseases and disorders
CCK2 receptors have links to anxiety disorders and gastric cancers. Alterations in receptor function can influence the brain's response to stress linking it to anxiety. For gastric cancers overexpression of CCK2 receptors can lead to increased cell proliferation. Their interaction with phosphoinositide 3-kinase also plays a role in the progression of gastric cancers.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCK2-R antibody (ab183124)
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling CCK2-R with ab183124 at 1/75 dilution. The image on the right is treated with the synthesized peptide. (Original magnification: X 200)
Western blot - Anti-CCK2-R antibody (ab183124)
10%SDS-PAGE
All lanes: Western blot - Anti-CCK2-R antibody (ab183124) at 1/1600 dilution
All lanes: Human gastric cancer tissue at 40 µg
SecondaryAll lanes: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Developed using the ECL technique.
Predicted band size: 48 kDa
Exposure time: 10s
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