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AB117412

Anti-CCK4 antibody

4

(7 Reviews)

|

(1 Publication)

Rabbit Polyclonal CCK4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human PTK7.

View Alternative Names

CCK4, PTK7, Inactive tyrosine-protein kinase 7, Colon carcinoma kinase 4, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, CCK-4

1 Images
Western blot - Anti-CCK4 antibody (AB117412)
  • WB

Supplier Data

Western blot - Anti-CCK4 antibody (AB117412)

All lanes:

Western blot - Anti-CCK4 antibody (ab117412) at 1/500 dilution

Lane 1:

MCF7 cells extracts

Lane 2:

T4D7 cells extracts

Predicted band size: 118 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Native Full Length Protein corresponding to Human PTK7.

Q13308

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
The anti-serum was pre-cleared for tag protein and then affinity purified on immobilized PTK7 affinity chromatography.
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCK4 also known as PTK7 protein is a receptor tyrosine kinase. The molecular mass of the CCK4 protein is approximately 118 kDa. It is expressed in various tissues including the placenta lung kidney and colon. The presence of CCK4 is particularly noted in developmental tissues and has roles in embryogenesis. Despite its classification as a receptor tyrosine kinase CCK4 lacks catalytic activity indicating its unique functional properties.
Biological function summary

CCK4 participates in cellular signaling involved in adhesion and cell migration. It localizes predominantly in the membranes participating in complex cellular environments such as the Wnt signaling complex. This suggests a role in maintaining cellular architecture and signaling pathways that influence developmental processes. Its interactions within these complexes can help maintain balance and functional integrity in developing tissues.

Pathways

CCK4 engages in vital pathways influencing cell adhesion and movement including the planar cell polarity (PCP) pathway and Wnt signaling pathway. Within these pathways CCK4 interacts with proteins such as Dishevelled and Frizzled establishing its role in guiding cellular and developmental patterns. These interactions regulate important aspects of cell polarity and directional movement during embryonic development.

CCK4 has been implicated in cancer and congenital malformations. In cancers such as colorectal carcinoma altered CCK4 expression correlates with cancer progression possibly through interaction with associated proteins like ROR2. Similarly its function in neural tube development suggests a role in congenital disorders affecting the spine and nervous system. This connection highlights the importance of CCK4 in both cancer biology and developmental disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
See full target information PTK7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Plant journal : for cell and molecular biology 90:304-318 PubMed28112445

2017

Calcium-dependent protein kinase CPK28 targets the methionine adenosyltransferases for degradation by the 26S proteasome and affects ethylene biosynthesis and lignin deposition in Arabidopsis.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Jin,Nenghui Ye,Fuyuan Zhu,Haoxuan Li,Juan Wang,Liwen Jiang,Jianhua Zhang
View all publications
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