AB233099

Anti-CCL18 antibody

Name: Anti-CCL18 antibody (ab233099) | Abcam
Brand: Abcam Limited
SKU: AB233099

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(5 Publications)

Rabbit Polyclonal CCL18 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCL18.

View Alternative Names

AMAC1, DCCK1, MIP4, PARC, SCYA18, CCL18, C-C motif chemokine 18, Alternative macrophage activation-associated CC chemokine 1, CC chemokine PARC, Dendritic cell chemokine 1, Macrophage inflammatory protein 4, Pulmonary and activation-regulated chemokine, Small-inducible cytokine A18, AMAC-1, DC-CK1, MIP-4

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL18 antibody (AB233099)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL18 antibody (AB233099)

Formalin-fixed, paraffin-embedded human lung tissue stained for CCL18 using ab233099 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-CCL18 antibody (AB233099)

All lanes:

Western blot - Anti-CCL18 antibody (ab233099) at 2 µg/mL

All lanes:

Human leukocyte lysate

Predicted band size: 10 kDa

false

Supplier Data

Western blot - Anti-CCL18 antibody (AB233099)

All lanes:

Western blot - Anti-CCL18 antibody (ab233099) at 2 µg/mL

All lanes:

Mouse lymphocyte lysate

Predicted band size: 10 kDa

false

Supplier Data

Western blot - Anti-CCL18 antibody (AB233099)

All lanes:

Western blot - Anti-CCL18 antibody (ab233099) at 2 µg/mL

All lanes:

Recombinant human CCL18

Predicted band size: 10 kDa

false

Supplier Data

Western blot - Anti-CCL18 antibody (AB233099)

All lanes:

Western blot - Anti-CCL18 antibody (ab233099) at 2 µg/mL

All lanes:

Human lung lysate

Predicted band size: 10 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CCL18.

P55774

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCL18 also known as pulmonary and activation-regulated chemokine (PARC) is a chemokine protein with a molecular weight of about 8.8 kDa. It is mainly expressed in the lung but also found in lymph nodes and placenta. CCL18 is secreted by activated macrophages and dendritic cells. As a chemokine it plays a role in immune system signaling where it attracts immune cells like T lymphocytes. Researchers utilize CCL18 ELISA kits to accurately measure its levels in biological samples providing insight into its functions.

Biological function summary

CCL18 plays an important role in modulating immune responses and recruiting immune cells to sites of inflammation. It is not part of a larger complex but works closely with other components of the immune system. CCL18 influences the activity of monocytes and the differentiation of T cells which are essential for mounting effective defense against pathogens. In inflammatory conditions increased CCL18 levels suggest its importance in controlling the magnitude and duration of immune responses.

Pathways

CCL18 is involved in the immune response and inflammatory pathways. It works particularly in chemokine signaling pathways and shares functional relations with proteins like CCR3 and CCR6 which act as receptors for various chemokines. The binding of CCL18 to these receptors on targeted cells facilitates the chemotaxis of immune cells steering the immune response to appropriate areas in the body where they are needed.

CCL18 has known associations with pulmonary fibrosis and various cancers. In pulmonary fibrosis CCL18 levels correlate with disease severity and progression indicating its potential role as a biomarker. The protein interacts with other signaling molecules including collagen and matrix metalloproteinases driving the fibrotic process. In cancers especially breast cancer high CCL18 expression often corresponds to tumor progression and metastasis. These interactions highlight its relevance not only in disease progression but also as a target for therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

See full target information CCL18

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 25:95 PubMed40089803

2025

ZEB1 promotes the immune escape of ovarian cancer through the MCSF-CCL18 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Ping Jin,Guo-Wei Li,Qian-Qian Xu,Xiao-Lan Wang

European journal of histochemistry : EJH 68: PubMed39105608

2024

CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yangying Peng,Shaojie Ding,Ping Xu,Xueyan Zhang,Jianzhang Wang,Tiantian Li,Liyun Liao,Xinmei Zhang

BMC ophthalmology 23:2 PubMed36597071

2023

Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Binghua Yang,Yuxia Fan,Renlong Liang,Yi Wu,Aiping Gu

Animal science journal = Nihon chikusan Gakkaiho 93:e13754 PubMed35791780

2022

The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high-grain diet.

Applications

Unspecified application

Species

Unspecified reactive species

Changxin Tian,Jian Wu,Jinzhen Jiao,Chuanshe Zhou,Zhiliang Tan

Nature communications 12:4977 PubMed34404786

2021

Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Xunyao Wu,Yi Liu,Shanzhao Jin,Min Wang,Yuhao Jiao,Bo Yang,Xin Lu,Xin Ji,Yunyun Fei,Huaxia Yang,Lidan Zhao,Hua Chen,Yaran Zhang,Hao Li,Peter E Lipsky,George C Tsokos,Fan Bai,Xuan Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCL18 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL18 antibody (AB233099)

Western blot - Anti-CCL18 antibody (AB233099)

Western blot - Anti-CCL18 antibody (AB233099)

Western blot - Anti-CCL18 antibody (AB233099)

Western blot - Anti-CCL18 antibody (AB233099)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

Primary Antibodies

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise