AB9849

Anti-CCL18 antibody

Name: Anti-CCL18 antibody (ab9849) | Abcam
Brand: Abcam Limited
SKU: AB9849
Price: 525 USD
Availability: InStock

Be the first to review this product! Submit a review

(4 Publications)

Rabbit Polyclonal CCL18 antibody. Suitable for ELISA, WB, sELISA and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Full Length Protein corresponding to Human CCL18.

View Alternative Names

AMAC1, DCCK1, MIP4, PARC, SCYA18, CCL18, C-C motif chemokine 18, Alternative macrophage activation-associated CC chemokine 1, CC chemokine PARC, Dendritic cell chemokine 1, Macrophage inflammatory protein 4, Pulmonary and activation-regulated chemokine, Small-inducible cytokine A18, AMAC-1, DC-CK1, MIP-4

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

Unknown

Light chain type

unknown

Carrier free

Reacts with

Human

Applications

ELISA, sELISA, WB

applications

Immunogen

Full Length Protein corresponding to Human CCL18. The exact immunogen used to generate this antibody is proprietary information.

P55774

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "To detect CCL18 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with an appropriate detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant CCL18. ." } } }

style

left-column

style

left-column

Properties and storage information

Form

Lyophilized

Reconstitution

Reconstitute with 200µl of sterile water.

Purification technique

Affinity purification Immunogen

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCL18 also known as pulmonary and activation-regulated chemokine (PARC) is a chemokine protein with a molecular weight of about 8.8 kDa. It is mainly expressed in the lung but also found in lymph nodes and placenta. CCL18 is secreted by activated macrophages and dendritic cells. As a chemokine it plays a role in immune system signaling where it attracts immune cells like T lymphocytes. Researchers utilize CCL18 ELISA kits to accurately measure its levels in biological samples providing insight into its functions.

Biological function summary

CCL18 plays an important role in modulating immune responses and recruiting immune cells to sites of inflammation. It is not part of a larger complex but works closely with other components of the immune system. CCL18 influences the activity of monocytes and the differentiation of T cells which are essential for mounting effective defense against pathogens. In inflammatory conditions increased CCL18 levels suggest its importance in controlling the magnitude and duration of immune responses.

Pathways

CCL18 is involved in the immune response and inflammatory pathways. It works particularly in chemokine signaling pathways and shares functional relations with proteins like CCR3 and CCR6 which act as receptors for various chemokines. The binding of CCL18 to these receptors on targeted cells facilitates the chemotaxis of immune cells steering the immune response to appropriate areas in the body where they are needed.

CCL18 has known associations with pulmonary fibrosis and various cancers. In pulmonary fibrosis CCL18 levels correlate with disease severity and progression indicating its potential role as a biomarker. The protein interacts with other signaling molecules including collagen and matrix metalloproteinases driving the fibrotic process. In cancers especially breast cancer high CCL18 expression often corresponds to tumor progression and metastasis. These interactions highlight its relevance not only in disease progression but also as a target for therapeutic interventions.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

See full target information CCL18

style

left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 77:3605-3618 PubMed28512246

2017

Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Nie,Jianing Chen,Di Huang,Yandan Yao,Jiewen Chen,Lin Ding,Jiayi Zeng,Shicheng Su,Xue Chao,Fengxi Su,Herui Yao,Hai Hu,Erwei Song

Cancer research 77:3591-3604 PubMed28484077

2017

Epstein-Barr Virus-Induced VEGF and GM-CSF Drive Nasopharyngeal Carcinoma Metastasis via Recruitment and Activation of Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Di Huang,Shi-Jian Song,Zi-Zhao Wu,Wei Wu,Xiu-Ying Cui,Jia-Ning Chen,Mu-Sheng Zeng,Shi-Cheng Su

Cell research 27:461-482 PubMed28290464

2017

Blocking the recruitment of naive CD4 T cells reverses immunosuppression in breast cancer.

Applications

Species

Human

Shicheng Su,Jianyou Liao,Jiang Liu,Di Huang,Chonghua He,Fei Chen,LinBing Yang,Wei Wu,Jianing Chen,Ling Lin,Yunjie Zeng,Nengtai Ouyang,Xiuying Cui,Herui Yao,Fengxi Su,Jian-Dong Huang,Judy Lieberman,Qiang Liu,Erwei Song

Cancer cell 25:605-20 PubMed24823638

2014

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Shicheng Su,Qiang Liu,Jingqi Chen,Jianing Chen,Fei Chen,Chonghua He,Di Huang,Wei Wu,Ling Lin,Wei Huang,Jin Zhang,Xiuying Cui,Fang Zheng,Haiyan Li,Herui Yao,Fengxi Su,Erwei Song

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCL18 antibody

Key facts

Host species

Clonality

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Reconstitution

Purification technique

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Alternative Products

Primary Antibodies

Complementary Products

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise