AB199167

Anti-CCL23 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal CCL23 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CCL23.

View Alternative Names

MIP3, MPIF1, SCYA23, CCL23, C-C motif chemokine 23, CK-beta-8, Macrophage inflammatory protein 3, Myeloid progenitor inhibitory factor 1, Small-inducible cytokine A23, CKB-8, MIP-3, MPIF-1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL23 antibody - C-terminal (AB199167)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL23 antibody - C-terminal (AB199167)

Immunohistochemical analysis of paraffin-embedded Human lymphoma tissue labeling CCL23 with ab199167 at 1/50 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL23 antibody - C-terminal (AB199167)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling CCL23 with ab199167 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CCL23. The exact immunogen used to generate this antibody is proprietary information.

P55773

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCL23 also known as macrophage inflammatory protein 3 is a chemokine involved in immune response regulation. It has a molecular weight of approximately 15-16 kDa and is secreted by various cells such as macrophages dendritic cells and endothelial cells. CCL23 is expressed mostly in the bone marrow and lymph nodes but it also localizes in tissues like the liver and lungs under certain conditions. It plays an important role in mediating chemotaxis directing the migration of cells toward infection sites.

Biological function summary

CCL23 functions in the recruitment of immune cells especially eosinophils and monocytes to areas where immune responses are necessary. This chemokine is not known to be part of a larger protein complex but its ability to interact with specific receptors on cell surfaces makes it integral to immune signaling. During immune activation CCL23 contributes to the inflammatory cascade influencing both acute and chronic inflammatory responses.

Pathways

The signaling functions of CCL23 integrate within the chemokine signaling pathway and the broader immune response pathway. CCL23 interacts closely with proteins such as CCR1 which acts as its receptor and influences cellular responses via this receptor-mediated signaling. Additionally CCL23 shares mechanistic parallels with other chemokines like CCL22 though they may attract different subsets of cells they participate in coordinated immune activities.

CCL23 has relevance to conditions such as rheumatoid arthritis and allergic reactions. In these diseases elevated levels of CCL23 and its interaction with other proteins such as CCR1 contribute to the recruitment and activation of inflammatory cells. This chemokine's role in immune cell trafficking and inflammation makes it a target for therapeutic interventions aimed at modulating immune responses in such disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23.

See full target information CCL23

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

NPJ genomic medicine 7:56 PubMed36171217

2022

Alternative ANKHD1 transcript promotes proliferation and inhibits migration in uterine corpus endometrial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenhuizi Sun,Runzhi Huang,Zhenyu Li,Yaru Zhu,Yan Bai,Siyu Wu,Jingshuai Wang,Yan Xiao,Shuyuan Xian,Xiaowen Tong,Jie Zhang,Yi Guo,Yiqin Ouyang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCL23 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL23 antibody - C-terminal (AB199167)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL23 antibody - C-terminal (AB199167)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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