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AB232837

Anti-CCL28/MEC antibody

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(3 Publications)

Rabbit Polyclonal CCL28/MEC antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CCL28 aa 1 to C-terminus.

View Alternative Names

SCYA28, CCL28, C-C motif chemokine 28, Mucosae-associated epithelial chemokine, Protein CCK1, Small-inducible cytokine A28, MEC

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL28/MEC antibody (AB232837)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL28/MEC antibody (AB232837)

Formalin-fixed, paraffin-embedded human lung tissue stained for CCL28/MEC using ab232837 at 20μg/ml in immunohistochemical analysis.

Western blot - Anti-CCL28/MEC antibody (AB232837)
  • WB

Supplier Data

Western blot - Anti-CCL28/MEC antibody (AB232837)

All lanes:

Western blot - Anti-CCL28/MEC antibody (ab232837) at 2 µg/mL

All lanes:

Recombinant human CCL28/MEC protein

Predicted band size: 14 kDa

false

Western blot - Anti-CCL28/MEC antibody (AB232837)
  • WB

Supplier Data

Western blot - Anti-CCL28/MEC antibody (AB232837)

All lanes:

Western blot - Anti-CCL28/MEC antibody (ab232837) at 2 µg/mL

All lanes:

Pig spleen tissue lysate

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CCL28 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NRJ3

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCL28 also known as MEC (Mucosae-associated epithelial chemokine) is a chemokine weighing around 12 kDa. It plays a mechanical role in mediating cell chemotaxis promoting the migration of cells towards it. This chemokine predominantly expresses in mucosal tissues including the salivary glands intestines and respiratory tract epithelia. CCL28 interacts specifically with chemokine receptors CCR10 and CCR3 guiding immune cells to these mucosal surfaces where they perform important immune functions.
Biological function summary

CCL28 plays an important role in mucosal immunity and is involved in the defense against pathogens in these environments. The chemokine attracts lymphocytes and neutrophils aiding in their positioning at mucosal sites. This activity assists in maintaining a balanced immune response preventing excessive inflammation while ensuring adequate pathogen clearance. CCL28 is not part of a larger protein complex but performs critical functions independently coordinating with other immune mediators for effective response.

Pathways

The function of CCL28 aligns with its involvement in immune signaling and mucosal defense pathways. The chemokine integrates into the immune response network working closely with other chemokines and cytokines like CCL27 and IL-8. It engages in the chemokine signaling pathway which regulates leukocyte migration and positioning. The interplay between CCL28 and these immune mediators ensures proper protection of mucosal surfaces from potential pathogens.

CCL28 holds significant relevance in inflammatory bowel disease (IBD) and allergic rhinitis. In IBD the chemokine contributes to the infiltration of immune cells into the inflamed gut mucosa where its interaction with other cytokines such as TNF-α exacerbates tissue inflammation. In allergic rhinitis CCL28 participates in recruiting eosinophils to the nasal mucosa often correlating with heightened inflammatory responses in these patients and cooperating with proteins like IL-5 to sustain the allergic reaction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
See full target information CCL28
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer biology & therapy 26:2483989 PubMed40140347

2025

Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP.

Applications

Unspecified application

Species

Unspecified reactive species

Jasmine M Manouchehri,Jharna Datta,Lynn M Marcho,Daniel Stover,Ramesh K Ganju,Bhuvaneswari Ramaswamy,William E Carson,Arjun Mittra,Xiaoli Zhang,Patrick M Schnell,Yu Yue,Mark P Rubinstein,Mathew A Cherian

Discover oncology 15:324 PubMed39085670

2024

CCL28 promotes progression of hepatocellular carcinoma through PDGFD-regulated MMP9 and VEGFA pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Youyi Liu,Xingyi Chen,Xiading Zhang,Jingrou Guo,Yifei Tang,Cheng Jin,Minchen Wu

Journal of healthcare engineering 2022:2580419 PubMed35494513

2022

Expression of CX3CL1 and CCL28 in Spinal Metastases of Lung Adenocarcinoma and Their Correlation with Clinical Features and Prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Shuguang Li,Shuai Liu,Jianjun Xun,Feifei Zhao
View all publications
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Product promise

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