AB32609

Anti-CCL3 / MIP-1 alpha antibody

Name: Anti-CCL3 / MIP-1 alpha antibody (ab32609) | Abcam
Brand: Abcam Limited
SKU: AB32609
Price: 515 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(9 Publications)

Rabbit Polyclonal MIP-1 alpha/CCL3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 9 publications.

View Alternative Names

G0S19-1, MIP1A, SCYA3, CCL3, C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, Macrophage inflammatory protein 1-alpha, PAT 464.1, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein, MIP-1-alpha

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Macaque monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MIP-1 alpha also known as CCL3 is a chemokine that plays a critical role in the immune system. With a molecular weight of around 8 kDa it is primarily expressed in activated T-cells macrophages and fibroblasts. MIP-1 alpha acts as a signaling protein that binds to receptors on target cells directing the movement of immune cells. Researchers commonly refer to it using various alternative names such as MIP-1a and CCL3-alpha rat and it is frequently measured using assays like MIP-1 alpha ELISA for experimental analyses.

Biological function summary

Proteins including MIP-1 alpha participate in the recruitment and activation of diverse immune cells aiding the inflammatory response. Through interaction with receptors like CCR1 and CCR5 MIP-1 alpha mobilizes cells like natural killer cells and monocytes. This chemokine does not generally form part of a larger protein complex but interacts directly with membrane receptors to exert its function in immune cell chemotaxis.

Pathways

MIP-1 alpha operates in the context of both the inflammatory response and the chemokine signaling pathways. Its involvement in these pathways helps mediate the trafficking of leukocytes. Notably MIP-1 alpha interacts with proteins such as CCR1 and CCR5 to transmit signals that instigate immune responses. These proteins are integral to its role in modulating immunity providing targets for research into controlling inflammatory processes.

MIP-1 alpha closely relates to conditions such as rheumatoid arthritis and HIV infection. In rheumatoid arthritis its overexpression can lead to excessive inflammation and joint destruction. Meanwhile in HIV infection MIP-1 alpha interacts with CCR5 a co-receptor necessary for the virus entry into cells. This dual relationship elucidates its potential as a therapeutic target in managing both inflammatory diseases and viral entry mechanisms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

See full target information CCL3

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

BMC medicine 23:213 PubMed40223064

2025

Plasma CCL3 predicts adverse heart failure outcomes in patients with arrhythmogenic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Cui,Songren Shu,Ningning Zhang,Mangyuan Wang,Tianshuo Yang,Zhen Wang,Xiao Chen,Mengxia Fu,Mengda Xu,Yicheng Yang,Peizhi Wang,Chuangshi Wang,Qiaoxi Yang,Huimin Gao,Yao Jiang,Jiangping Song

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2406684 PubMed39465672

2024

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiqi Li,Fan Gu,Linlin Peng,Tingting Huan,Zhuo Zhou,Yaling Song,Jinmei He,Kaili Ye,Yao Sun,Tiejun Li,Miao He,Zhuan Bian,Wei Yin

Contrast media & molecular imaging 2022:2387192 PubMed35935327

2022

CCL3 Promotes Proliferation of Colorectal Cancer Related with TRAF6/NF-B Molecular Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoqiang Ma,Jinda Su,Shaohui Zhao,Yaqin He,Shuzhen Li,Xiaoliang Yang,Sifan Zhai,Shikuo Rong,Xin Zhang,Guangxian Xu,Xiaoliang Xie

Nature communications 12:4977 PubMed34404786

2021

Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Xunyao Wu,Yi Liu,Shanzhao Jin,Min Wang,Yuhao Jiao,Bo Yang,Xin Lu,Xin Ji,Yunyun Fei,Huaxia Yang,Lidan Zhao,Hua Chen,Yaran Zhang,Hao Li,Peter E Lipsky,George C Tsokos,Fan Bai,Xuan Zhang

JOR spine 3:e1098 PubMed33015573

2020

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Abbie Binch,Joseph Snuggs,Christine L Le Maitre

Cells 9: PubMed32183151

2020

The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Marielle Saclier,Michela Lapi,Chiara Bonfanti,Giuliana Rossi,Stefania Antonini,Graziella Messina

The Journal of clinical investigation 130:1156-1167 PubMed32015229

2020

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation.

Applications

Unspecified application

Species

Unspecified reactive species

Simon McArthur,Gaëtan Juban,Thomas Gobbetti,Thibaut Desgeorges,Marine Theret,Julien Gondin,Juliana E Toller-Kawahisa,Chris P Reutelingsperger,Bénédicte Chazaud,Mauro Perretti,Rémi Mounier

Cell reports 25:2163-2176.e6 PubMed30463013

2018

AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Gaëtan Juban,Marielle Saclier,Houda Yacoub-Youssef,Amel Kernou,Ludovic Arnold,Camille Boisson,Sabrina Ben Larbi,Mélanie Magnan,Sylvain Cuvellier,Marine Théret,Basil J Petrof,Isabelle Desguerre,Julien Gondin,Rémi Mounier,Bénédicte Chazaud

International journal of oncology 40:1995-2003 PubMed22307528

2012

Identification of blood protein biomarkers that aid in the clinical assessment of patients with malignant glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Baogang J Xu,Qi A An,Supriya Srinivasa Gowda,Wenwei Yan,Larry A Pierce,Ty W Abel,Sarah Z Rush,Michael K Cooper,Fei Ye,Yu Shyr,Kyle D Weaver,Reid C Thompson

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCL3 / MIP-1 alpha antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

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