Rabbit Polyclonal CL3L1 antibody. C-terminal. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human CCL3L1 aa 50 to C-terminus.
IgG
Rabbit
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Liquid
Polyclonal
WB | |
---|---|
Mouse | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
D17S1718, G0S19-2, SCYA3L1, CCL3L3, CCL3L1, C-C motif chemokine 3-like 1, G0/G1 switch regulatory protein 19-2, LD78-beta(1-70), PAT 464.2, Small-inducible cytokine A3-like 1, Tonsillar lymphocyte LD78 beta protein
Rabbit Polyclonal CL3L1 antibody. C-terminal. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human CCL3L1 aa 50 to C-terminus.
IgG
Rabbit
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
CCL3L1 also known as chemokine (C-C motif) ligand 3-like 1 is a protein encoded by the CCL3L1 gene. This chemokine weighs approximately 10 kDa. CCL3L1 binds to chemokine receptors CCR1 and CCR5 on the surface of target cells. It is secreted by various cells such as macrophages T-cells and dendritic cells. Mainly it expresses in tissues involved in immune responses including lymph nodes and spleen.
CCL3L1 plays an important role in mediating immune responses. It attracts immune cells like monocytes neutrophils and T-lymphocytes to sites of infection or injury enhancing the immune defense. Although CCL3L1 does not form part of a larger protein complex it acts as a critical signaling molecule in the immune system. Its interaction with CCR5 makes it an important component in inflammatory responses and leukocyte chemotaxis.
CCL3L1 functions as a significant participant in cytokine-cytokine receptor interactions and chemokine signaling pathways. These pathways regulate the movement and activity of immune cells in response to specific chemokine signals. Through these pathways CCL3L1 interacts with other chemokines such as CCL4 supporting the coordination of immune cell trafficking to inflamed tissues. This involvement is essential for maintaining the proper function of the immune response.
CCL3L1 is associated with susceptibility to HIV infection and rheumatoid arthritis. Variations in the CCL3L1 gene copy number can alter individual risk to HIV as this protein competes for binding with the HIV-1 virus on the CCR5 receptor effectively impeding viral entry. Additionally the overexpression of CCL3L1 contributes to the inflammatory environment observed in rheumatoid arthritis by recruiting more immune cells to affected joints and it interacts with proteins like TNF-α in the inflammatory cascade.
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All lanes: Western blot - Anti-CCL3L1 antibody - C-terminal (ab182789) at 1/700 dilution
All lanes: RAW 264.7 cell at 40 µg
All lanes: Goat anti Rabbit IgG at 1/10000 dilution
Predicted band size: 10 kDa
Exposure time: 45s
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