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AB71977

Anti-CCNB1IP1 antibody

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(6 Publications )

Mouse Polyclonal CCNB1IP1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCNB1IP1.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CCNB1IP1.

Q9NPC3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCNB1IP1 also known as HEI10 is a protein that functions mechanically as an E3 ubiquitin-protein ligase. It plays a role in tagging proteins for degradation. This protein weighs approximately 28 kDa. CCNB1IP1 is mainly expressed in the testis indicating its importance in reproductive organ function. The regulation and activity of CCNB1IP1 are critical in the control of cellular processes particularly those related to cell cycle progression.
Biological function summary

The protein CCNB1IP1 is involved in homologous recombination during meiosis. It is a part of a complex that includes proteins responsible for the repair and reorganization of DNA strands. Its activity ensures accurate chromosome segregation and genetic diversity during the formation of gametes. The presence of CCNB1IP1 in this recombination complex underlines its role in maintaining genomic stability.

Pathways

CCNB1IP1 participates in the DNA Damage Response pathway which is essential for detecting and repairing DNA lesions. It is also involved in the meiotic recombination checkpoint pathway ensuring accurate cell division. During these pathways CCNB1IP1 interacts with several other proteins such as RAD51 and DMC1 critical to DNA strand exchange and repair. These interactions position CCNB1IP1 as a central player in maintaining cell integrity during meiosis.

Mutations or dysregulation of CCNB1IP1 are linked to reproductive disorders particularly male infertility due to disrupted meiotic recombination. CCNB1IP1 is also studied in relation to certain cancers as defects in meiotic processes can result in genomic instability observed in tumorigenesis. The relationship between CCNB1IP1 mutations and these conditions often involves other proteins like BRCA2 which plays a role in homologous recombination repair highlighting potential shared genetic pathways in disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis : required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
See full target information CCNB1IP1

Alternative Names

C14orf18, HEI10, CCNB1IP1, E3 ubiquitin-protein ligase CCNB1IP1, Cyclin-B1-interacting protein 1, Human enhancer of invasion 10, RING-type E3 ubiquitin transferase CCNB1IP1
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112878 PubMed40686610

2025

UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaochen Yu,Jie Cen,Yaxuan Zhang,Tongtong Li,Mingyu Zhang,Fei Gao,Hongbin Liu,Yongzhi Cao

PloS one 18:e0283590 PubMed36952545

2023

Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity.

Applications

Unspecified application

Species

Unspecified reactive species

Nathan Palmer,S Zakiah A Talib,Christine M F Goh,Kajal Biswas,Shyam K Sharan,Philipp Kaldis

Cell reports 32:107858 PubMed32640224

2020

Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen Gray,Emerson R Santiago,Joshua S Chappie,Paula E Cohen

Aging 12:3025-3041 PubMed32045367

2020

Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shanzhou Huang,Chuanzhao Zhang,Chengjun Sun,Yuchen Hou,Yixi Zhang,Nga Lei Tam,Zekang Wang,Jia Yu,Bowen Huang,Hongkai Zhuang,Zixuan Zhou,Zuyi Ma,Zhonghai Sun,Xiaoshun He,Qi Zhou,Baohua Hou,Linwei Wu

PLoS genetics 15:e1008177 PubMed31170160

2019

A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa Toledo,Xianfei Sun,Miguel A Brieño-Enríquez,Vandana Raghavan,Stephen Gray,Jeffrey Pea,Carolyn R Milano,Anita Venkatesh,Lekha Patel,Peter L Borst,Eric Alani,Paula E Cohen

Biomedicine & pharmacotherapy = Biomedecine & phar 105:887-898 PubMed30021382

2018

MiR-373-3p enhances the chemosensitivity of gemcitabine through cell cycle pathway by targeting CCND2 in pancreatic carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjie Hu,Qilong Liu,Jie Pan,Zheng Sui
View all publications
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Product promise

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