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AB219854

Anti-CCPG1 antibody

1

(1 Review)

|

(2 Publications)

Rabbit Polyclonal CCPG1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CCPG1 aa 250-400.

View Alternative Names

CCP8, CPR8, KIAA1254, CCPG1, Cell cycle progression protein 1, Cell cycle progression restoration protein 8

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-CCPG1 antibody (AB219854)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CCPG1 antibody (AB219854)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized HeLa cells labeling CCPG1 with ab219854 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CCPG1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q9ULG6

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Secondary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCPG1 also known as cell cycle progression 1 is a protein that plays an essential role in cellular functions. It has a molecular mass of about 81 kDa. This protein regulates the cell cycle and modulates transcriptional activation which is important for cell division and growth. CCPG1 is expressed in several tissues including liver and skeletal muscles indicating its importance across various biological processes. Its regulation impacts cell cycle phases particularly the transition from G1 to S phase which ensures proper cell division and function.
Biological function summary

CCPG1 serves an important role in maintaining cellular homeostasis and participates in endoplasmic reticulum (ER) stress response. It acts as a mediator for autophagy where it assists in disposing of misfolded proteins. CCPG1 works as a part of a complex machinery interacting with other molecules to ensure that autophagic processes run smoothly in stress conditions. The protein also modulates interactions with the Golgi apparatus and influences protein traffic further emphasizing its broad impact on cellular mechanics.

Pathways

Studies demonstrate that CCPG1 contributes significantly to the autophagy pathway where it interacts with key proteins like LC3. This protein's involvement in endoplasmic-reticulum-associated degradation (ERAD) connects it to proteostasis pathways working alongside proteins like ATG16L1 to maintain cellular equilibrium. CCPG1 influences these pathways by facilitating degradation of misfolded proteins which aids in maintaining cellular stress responses.

Multiple researchers linked CCPG1 to neurodegenerative conditions like Alzheimer's disease. Its role in autophagy and protein homeostasis suggests a connection to neurodegeneration potentially because disrupted CCPG1 function might lead to accumulation of toxic proteins. Additionally CCPG1 displays a relationship with inflammatory disorders where improper regulation could increase cellular inflammation. In both contexts CCPG1 interacts with key proteins involved in disease mechanisms such as ATG5 in autophagy or NF-κB in inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.
See full target information CCPG1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

eLife 10: PubMed34259627

2021

CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.

Applications

Unspecified application

Species

Unspecified reactive species

André Brás Gonçalves,Sarah Kirstine Hasselbalch,Beinta Biskopstø Joensen,Sebastian Patzke,Pernille Martens,Signe Krogh Ohlsen,Mathieu Quinodoz,Konstantinos Nikopoulos,Reem Suleiman,Magnus Per Damsø Jeppesen,Catja Weiss,Søren Tvorup Christensen,Carlo Rivolta,Jens S Andersen,Pietro Farinelli,Lotte Bang Pedersen

Molecular brain 14:65 PubMed33823883

2021

Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Lim,Seolsong Kim,Eun-Kyoung Kim
View all publications
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Product promise

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