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AB19013

Anti-CCR1 antibody

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(7 Publications)

Rabbit Polyclonal CCR1 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human CCR1.

View Alternative Names

CD191, CMKBR1, CMKR1, SCYAR1, CCR1, C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, RANTES-R, MIP-1alpha-R

1 Images
Western blot - Anti-CCR1 antibody (AB19013)
  • WB

Supplier Data

Western blot - Anti-CCR1 antibody (AB19013)

All lanes:

Western blot - Anti-CCR1 antibody (ab19013)

All lanes:

Jurkat cell lysate

Predicted band size: 41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CCR1. The exact immunogen used to generate this antibody is proprietary information.

P32246

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3414 CCR1 Antibody. 3414-100 is the same size as the 100 µg size of ab19013.
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Properties and storage information

Form
Liquid
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target CCR1 also known as C-C chemokine receptor type 1 plays a mechanical role in mediating cellular responses to chemokines. It is a protein with a molecular mass of approximately 45 kDa. CCR1 expresses on a variety of cells including immune cells like monocytes macrophages and certain lymphocytes as well as some non-hematopoietic cells. This receptor resides on the cell membrane and contributes to the directed movement of these cells in response to chemokine gradients.
Biological function summary

CCR1 involves itself in processes such as leukocyte migration and inflammatory response. The receptor interacts with specific chemokines of the C-C motif like CCL3 and CCL5. CCR1 does not operate within a higher-order protein complex but binds directly to these chemokines leading to signal transduction that alters cell functions. By modulating immune cell behaviors CCR1 helps orchestrate immune surveillance and inflammation.

Pathways

CCR1 plays a significant part in immune-related pathways such as chemokine signaling and the inflammatory response. It transduces signals via G-protein coupled receptor pathways influencing downstream signaling molecules including PI3K and AKT. Apart from its direct chemokine interactions CCR1 regulates functions in concert with proteins like CCR5 another chemokine receptor coordinating the migration and activation of immune cells across tissues.

CCR1 contributes to conditions such as rheumatoid arthritis and multiple sclerosis. Its role in directing immune cell trafficking makes it a potential player in autoimmune inflammation observed in these diseases. CCR1's interaction with other proteins such as CCR5 and their combined roles in these conditions suggest a target for therapeutic intervention. Research continues to explore how modulating CCR1 activity might impact disease progression and symptom severity in affected individuals.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed : 14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed : 15905581). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4 (By similarity). Mediates also monocyte migration upon CXCL4 binding (PubMed : 29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity).
See full target information CCR1
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Genes & diseases 11:964-977 PubMed37692479

2023

deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling.

Applications

WB

Species

Mouse

Chengzhi Wu,Hengyu Liu,Dongmei Zhong,Xiaoming Yang,Zhiheng Liao,Yuyu Chen,Shun Zhang,Deying Su,Baolin Zhang,Chuan Li,Liru Tian,Caixia Xu,Peiqiang Su

Cancer science 112:3099-3110 PubMed34050704

2021

CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Meng,Lianghai Wang,Jun Hou,Xiaofeng Yang,Ke Lin,Hongxing Nan,Man Li,Xiangwei Wu,Xueling Chen

BMC complementary medicine and therapies 20:234 PubMed32703287

2020

Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengeng Liang,Yan Xue,Tao Wang,Qi Xie,Jiafu Lin,Yu Wang

The Journal of clinical investigation 128:1807-1819 PubMed29584619

2018

PAI1 mediates fibroblast-mast cell interactions in skin fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Neha Pincha,Edries Yousaf Hajam,Krithika Badarinath,Surya Prakash Rao Batta,Tafheem Masudi,Rakesh Dey,Peter Andreasen,Toshiaki Kawakami,Rekha Samuel,Renu George,Debashish Danda,Paul Mazhuvanchary Jacob,Colin Jamora

Evidence-based complementary and alternative medic 2017:3121989 PubMed28491104

2017

Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE Mice Fed with a High-Fat Diet.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhang,Pan Ren,Qunfu Kang,Weihong Liu,Sinai Li,Ping Li,Hongxu Liu,Juju Shang,Lei Zhang,Yanbing Gong,Mingxue Zhou

Frontiers in physiology 5:485 PubMed25566087

2014

Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise.

Applications

IHC

Species

Unspecified reactive species

Robert D Hyldahl,Ty Olson,Tyson Welling,Logan Groscost,Allen C Parcell

PloS one 5:e13751 PubMed21060787

2010

TGF-β1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.

Applications

IHC

Species

Unspecified reactive species

David A Barron,Douglas W Strand,Steven J Ressler,Truong D Dang,Simon W Hayward,Feng Yang,Gustavo E Ayala,Michael Ittmann,David R Rowley
View all publications
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