AB140784

Anti-CCR11 antibody - Cytoplasmic domain

Name: Anti-CCR11 antibody - Cytoplasmic domain (ab140784) | Abcam
Brand: Abcam Limited
SKU: AB140784

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(1 Publication)

Rabbit Polyclonal CCR11 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ACKR4.

View Alternative Names

CCBP2, CCR11, CCRL1, VSHK1, ACKR4, Atypical chemokine receptor 4, C-C chemokine receptor type 11, CC chemokine receptor-like 1, CCX CKR, C-C CKR-11, CC-CKR-11, CCR-11

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR11 antibody - Cytoplasmic domain (AB140784)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR11 antibody - Cytoplasmic domain (AB140784)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human heart tissue labelling CCR11 with ab140784 at 24 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ACKR4. The exact immunogen used to generate this antibody is proprietary information.

Q9NPB9

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CCR6 (63%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "24 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Opossum": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCR11 also known as chemokine (C-C motif) receptor 11 is a member of the large protein family of G protein-coupled receptors (GPCRs). This receptor has a molecular mass of approximately 45 kDa. It is primarily expressed on immune cells such as T cells dendritic cells and macrophages. CCR11 functions mainly by binding to specific chemokines small signaling proteins that guide the movement of circulating leukocytes to sites of inflammation or injury. The expression pattern helps mediate immune responses contributing to its pivotal role in the immune system.

Biological function summary

The movement and positioning of immune cells heavily depend on receptors like CCR11. It couples with chemokines to facilitate leukocyte migration and activation a necessary process during immune surveillance and response to pathogens. While not part of a larger protein complex CCR11 collaborates intimately with other chemokine receptors in orchestrating efficient immune responses. Its role highlights the importance of receptor-mediated chemotaxis in maintaining both innate and adaptive immunity.

Pathways

Chemotaxis and signaling cascades are essential areas where CCR11 participates actively. The receptor is a component of the chemokine signaling pathway interacting closely with other receptors like CCR7 and CCL19/CCL21 chemokines. It aligns with pathways such as those governing inflammation response and cell migration linking with proteins necessary for cellular communication in the immune network. CCR11's functionality within these pathways helps fine-tune immune cell trafficking.

Research identifies CCR11 as key in inflammatory diseases and certain cancers. The receptor's misregulation can contribute to chronic inflammatory conditions or tumor progression by affecting immune cell dynamics. Proteins like CCL5 known to interact with CCR11 have been implicated in these disease contexts aiding in the recruitment of immune cells to tumors. Understanding CCR11's role in such disorders provides insight into potential therapeutic interventions to modulate immune responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

See full target information ACKR4

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 128:5235-5250 PubMed30204129

2018

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Wang,Xiaoling Weng,Luoyang Wang,Mingang Hao,Yue Li,Lidan Hou,Yu Liang,Tianqi Wu,Mengfei Yao,Guowen Lin,Yiwei Jiang,Guohui Fu,Zhaoyuan Hou,Xiangjun Meng,Jinsong Lu,Jianhua Wang

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-CCR11 antibody - Cytoplasmic domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR11 antibody - Cytoplasmic domain (AB140784)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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