AB32564

Anti-CCR11 antibody [E100]

RabMAb
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(2 Publications)

Rabbit Monoclonal CCR11 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

CCBP2, CCR11, CCRL1, VSHK1, ACKR4, Atypical chemokine receptor 4, C-C chemokine receptor type 11, CC chemokine receptor-like 1, CCX CKR, C-C CKR-11, CC-CKR-11, CCR-11

1 Images

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Western blot - Anti-CCR11 antibody [E100] (AB32564)

All lanes:

Western blot - Anti-CCR11 antibody [E100] (ab32564) at 1/10000 dilution

All lanes:

K562 cell lysate

Predicted band size: 40 kDa

Observed band size: 45 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

E100

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

The antibody recognises CKRB/CKR11. It does not cross-react with other G-protein coupled receptor 1 family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCR11 also known as chemokine (C-C motif) receptor 11 is a member of the large protein family of G protein-coupled receptors (GPCRs). This receptor has a molecular mass of approximately 45 kDa. It is primarily expressed on immune cells such as T cells dendritic cells and macrophages. CCR11 functions mainly by binding to specific chemokines small signaling proteins that guide the movement of circulating leukocytes to sites of inflammation or injury. The expression pattern helps mediate immune responses contributing to its pivotal role in the immune system.

Biological function summary

The movement and positioning of immune cells heavily depend on receptors like CCR11. It couples with chemokines to facilitate leukocyte migration and activation a necessary process during immune surveillance and response to pathogens. While not part of a larger protein complex CCR11 collaborates intimately with other chemokine receptors in orchestrating efficient immune responses. Its role highlights the importance of receptor-mediated chemotaxis in maintaining both innate and adaptive immunity.

Pathways

Chemotaxis and signaling cascades are essential areas where CCR11 participates actively. The receptor is a component of the chemokine signaling pathway interacting closely with other receptors like CCR7 and CCL19/CCL21 chemokines. It aligns with pathways such as those governing inflammation response and cell migration linking with proteins necessary for cellular communication in the immune network. CCR11's functionality within these pathways helps fine-tune immune cell trafficking.

Research identifies CCR11 as key in inflammatory diseases and certain cancers. The receptor's misregulation can contribute to chronic inflammatory conditions or tumor progression by affecting immune cell dynamics. Proteins like CCL5 known to interact with CCR11 have been implicated in these disease contexts aiding in the recruitment of immune cells to tumors. Understanding CCR11's role in such disorders provides insight into potential therapeutic interventions to modulate immune responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

See full target information ACKR4

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 40:e106106 PubMed33709453

2021

Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.

Applications

Unspecified application

Species

Unspecified reactive species

Won-Seok Lee,Laura Lavery,Maxime W C Rousseaux,Eric B Rutledge,Youjin Jang,Ying-Wooi Wan,Sih-Rong Wu,Wonho Kim,Ismael Al-Ramahi,Smruti Rath,Carolyn J Adamski,Vitaliy V Bondar,Ambika Tewari,Shirin Soleimani,Samantha Mota,Hari K Yalamanchili,Harry T Orr,Zhandong Liu,Juan Botas,Huda Y Zoghbi

European urology 61:385-94 PubMed22079021

2011

T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6.

Applications

Unspecified application

Species

Unspecified reactive species

Kimberley A Oldham,Greg Parsonage,Rupesh I Bhatt,D Michael A Wallace,Nayneeta Deshmukh,Shalini Chaudhri,David H Adams,Steven P Lee

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCR11 antibody [E100]

Western blot - Anti-CCR11 antibody [E100] (AB32564)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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