Anti-CCR11 antibody [E100]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CCR11 also known as chemokine (C-C motif) receptor 11 is a member of the large protein family of G protein-coupled receptors (GPCRs). This receptor has a molecular mass of approximately 45 kDa. It is primarily expressed on immune cells such as T cells dendritic cells and macrophages. CCR11 functions mainly by binding to specific chemokines small signaling proteins that guide the movement of circulating leukocytes to sites of inflammation or injury. The expression pattern helps mediate immune responses contributing to its pivotal role in the immune system.

Biological function summary

The movement and positioning of immune cells heavily depend on receptors like CCR11. It couples with chemokines to facilitate leukocyte migration and activation a necessary process during immune surveillance and response to pathogens. While not part of a larger protein complex CCR11 collaborates intimately with other chemokine receptors in orchestrating efficient immune responses. Its role highlights the importance of receptor-mediated chemotaxis in maintaining both innate and adaptive immunity.

Pathways

Chemotaxis and signaling cascades are essential areas where CCR11 participates actively. The receptor is a component of the chemokine signaling pathway interacting closely with other receptors like CCR7 and CCL19/CCL21 chemokines. It aligns with pathways such as those governing inflammation response and cell migration linking with proteins necessary for cellular communication in the immune network. CCR11's functionality within these pathways helps fine-tune immune cell trafficking.

Associated diseases and disorders

Research identifies CCR11 as key in inflammatory diseases and certain cancers. The receptor's misregulation can contribute to chronic inflammatory conditions or tumor progression by affecting immune cell dynamics. Proteins like CCL5 known to interact with CCR11 have been implicated in these disease contexts aiding in the recruitment of immune cells to tumors. Understanding CCR11's role in such disorders provides insight into potential therapeutic interventions to modulate immune responses.