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AB284674

Anti-CCR11 antibody [E100] - BSA and Azide free

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Rabbit Monoclonal CCR11 antibody. Carrier free. Suitable for WB and reacts with Human samples.

View Alternative Names

CCBP2, CCR11, CCRL1, VSHK1, ACKR4, Atypical chemokine receptor 4, C-C chemokine receptor type 11, CC chemokine receptor-like 1, CCX CKR, C-C CKR-11, CC-CKR-11, CCR-11

1 Images
Western blot - Anti-CCR11 antibody [E100] - BSA and Azide free (AB284674)
  • WB

Unknown

Western blot - Anti-CCR11 antibody [E100] - BSA and Azide free (AB284674)

This data was developed using ab32564, the same antibody clone in a different buffer formulation.

All lanes:

Western blot - Anti-CCR11 antibody [E100] - BSA and Azide free (ab284674) at 1/10000 dilution

All lanes:

K562 cell lysate

Predicted band size: 40 kDa

Observed band size: 45 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

E100

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

The antibody recognises CKRB/CKR11. It does not cross-react with other G-protein coupled receptor 1 family members.

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Reactivity data

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Product details

ab284674 is the carrier-free version of ab32564

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCR11 also known as chemokine (C-C motif) receptor 11 is a member of the large protein family of G protein-coupled receptors (GPCRs). This receptor has a molecular mass of approximately 45 kDa. It is primarily expressed on immune cells such as T cells dendritic cells and macrophages. CCR11 functions mainly by binding to specific chemokines small signaling proteins that guide the movement of circulating leukocytes to sites of inflammation or injury. The expression pattern helps mediate immune responses contributing to its pivotal role in the immune system.
Biological function summary

The movement and positioning of immune cells heavily depend on receptors like CCR11. It couples with chemokines to facilitate leukocyte migration and activation a necessary process during immune surveillance and response to pathogens. While not part of a larger protein complex CCR11 collaborates intimately with other chemokine receptors in orchestrating efficient immune responses. Its role highlights the importance of receptor-mediated chemotaxis in maintaining both innate and adaptive immunity.

Pathways

Chemotaxis and signaling cascades are essential areas where CCR11 participates actively. The receptor is a component of the chemokine signaling pathway interacting closely with other receptors like CCR7 and CCL19/CCL21 chemokines. It aligns with pathways such as those governing inflammation response and cell migration linking with proteins necessary for cellular communication in the immune network. CCR11's functionality within these pathways helps fine-tune immune cell trafficking.

Research identifies CCR11 as key in inflammatory diseases and certain cancers. The receptor's misregulation can contribute to chronic inflammatory conditions or tumor progression by affecting immune cell dynamics. Proteins like CCL5 known to interact with CCR11 have been implicated in these disease contexts aiding in the recruitment of immune cells to tumors. Understanding CCR11's role in such disorders provides insight into potential therapeutic interventions to modulate immune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
See full target information ACKR4
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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