Rabbit Polyclonal CCR6 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human CCR6 aa 350 to C-terminus.
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- Frontiers in cellular and infection microbiology 11:5353522021Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJennifer P Bharucha,Lingling Sun,Wuyuan Lu,Suzanne Gartner,Alfredo Garzino-DemoPubMed 34277460
- Frontiers in oncology 11:6671742021Tongue Cancer Cell-Derived CCL20 Induced by Interaction With Macrophages Promotes CD163 Expression on Macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesManabu Shigeoka,Yu-Ichiro Koma,Takayuki Kodama,Mari Nishio,Masaya Akashi,Hiroshi YokozakiPubMed 34178651
- Scientific reports 10:213422020Stem cell characteristics promote aggressiveness of diffuse large B-cell lymphoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKung-Chao Chang et. al.PubMed 33288848
- Molecular medicine reports 22:1317-13242020Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJi Hyeon Ahn et. al.PubMed 32627009
- Frontiers in pharmacology 11:452020Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTengteng Wang et. al.PubMed 32116720
- Oncology reports 42:1946-19562019lncRNA‑u50535 promotes the progression of lung cancer by activating CCL20/ERK signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Wei et. al.PubMed 31545478
- Brain research bulletin 152:27-342019The Stat3 inhibitor, S3I-201, downregulates lymphocyte activation markers, chemokine receptors, and inflammatory cytokines in the BTBR T Itpr3/J mouse model of autism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSheikh F Ahmad et. al.PubMed 31299319
- Journal of neuroinflammation 16:1152019CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMahasweta Das et. al.PubMed 31151410
- Viruses 10:2018Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR) That Is Blocked by Interleukin-10.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHao Chen et. al.PubMed 30249047
- Biological research 51:122018In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuiying Diao et. al.PubMed 29788995
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide
Constituents: 2% Trehalose, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human CCR6 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P51684
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Tested |
| Dog | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.1-0.5 µg/mL | Notes - |
Species Human | Dilution info 0.1-0.5 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Dog | Dilution info - | Notes - |
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Target data
Function
Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
Alternative names
CD196, CKRL3, CMKBR6, GPR29, STRL22, CCR6, C-C chemokine receptor type 6, C-C CKR-6, CC-CKR-6, CCR-6, Chemokine receptor-like 3, DRY6, G-protein coupled receptor 29, GPR-CY4, LARC receptor, CKR-L3, GPRCY4
Recommended products
Rabbit Polyclonal CCR6 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human CCR6 aa 350 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide
Constituents: 2% Trehalose, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human CCR6 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P51684
- Purification technique
- Affinity purification Immunogen
- Specificity
No cross reactivity with other proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CCR6 also known as CD196 is a chemokine receptor with a molecular mass of approximately 44 kDa. This protein is primarily expressed on the surface of various immune cells including T cells B cells and dendritic cells. Through its interaction with its only known ligand CCL20 also known as MIP-3α CCR6 mediates chemotaxis which guides the targeted migration of cells to sites of inflammation or injury. In murine models (mouse) CCR6 expression helps researchers examine immune responses in vivo and its presence is detected using recombinant proteins or antibodies specific for CCR6 such as 'CCR6 antibodies' with techniques including flow cytometry utilizing labels like CCR6-APC or CCR6-fluorochrome.
- Biological function summary
CCR6 plays an essential role in the regulation of immune responses and maintaining mucosal immunity. It is involved in the recruitment of Th17 cells and dendritic cells to inflamed tissues which plays a critical role in initiating and sustaining immune responses. While CCR6 operates primarily as a standalone receptor its engagement influences diverse cellular functions linked to immune surveillance and tolerance. This receptor's expression on lymphoid tissue inducer cells indicates its relevance in the formation of secondary lymphoid organs and in dynamic interactions within the immune system.
- Pathways
CCR6 is a significant component in pathways related to immune cell trafficking and inflammatory responses particularly the MAPK/ERK pathway and the JAK/STAT pathway. In these pathways CCR6 often interacts with related proteins such as CCL20 and other chemokine receptors facilitating cellular migration and activation processes. These interactions underpin the migration of regulatory T cells and B cells which modulate inflammation and affect pathogen clearance ensuring a controlled immune response.
- Associated diseases and disorders
CCR6 has links to conditions such as autoimmune diseases with rheumatoid arthritis and inflammatory bowel disease being notable examples. In rheumatoid arthritis the dysregulated expression of CCR6 attracts Th17 cells into synovial tissues promoting inflammation. Meanwhile inflammatory bowel disease shows a similar pattern of CCR6-mediated chemotaxis that encourages Th17 cell recruitment. In these contexts CCR6 cooperates with other immune mediators like CCL20 to perpetuate disease-related inflammatory processes highlighting its potential as a therapeutic target in immune modulation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-CCR6 antibody (ab78429)
All lanes: Western blot - Anti-CCR6 antibody (ab78429) at 0.5 µg/mL
Lane 1: Rat Liver Tissue Lysate
Lane 2: SW620 Cell Lysate
Lane 3: CEM Cell Lysate
Predicted band size: 42 kDa
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