Anti-CCR6 antibody [EPR24085-145]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CCR6 also known as CD196 is a chemokine receptor with a molecular mass of approximately 44 kDa. This protein is primarily expressed on the surface of various immune cells including T cells B cells and dendritic cells. Through its interaction with its only known ligand CCL20 also known as MIP-3α CCR6 mediates chemotaxis which guides the targeted migration of cells to sites of inflammation or injury. In murine models (mouse) CCR6 expression helps researchers examine immune responses in vivo and its presence is detected using recombinant proteins or antibodies specific for CCR6 such as 'CCR6 antibodies' with techniques including flow cytometry utilizing labels like CCR6-APC or CCR6-fluorochrome.

Biological function summary

CCR6 plays an essential role in the regulation of immune responses and maintaining mucosal immunity. It is involved in the recruitment of Th17 cells and dendritic cells to inflamed tissues which plays a critical role in initiating and sustaining immune responses. While CCR6 operates primarily as a standalone receptor its engagement influences diverse cellular functions linked to immune surveillance and tolerance. This receptor's expression on lymphoid tissue inducer cells indicates its relevance in the formation of secondary lymphoid organs and in dynamic interactions within the immune system.

Pathways

CCR6 is a significant component in pathways related to immune cell trafficking and inflammatory responses particularly the MAPK/ERK pathway and the JAK/STAT pathway. In these pathways CCR6 often interacts with related proteins such as CCL20 and other chemokine receptors facilitating cellular migration and activation processes. These interactions underpin the migration of regulatory T cells and B cells which modulate inflammation and affect pathogen clearance ensuring a controlled immune response.

Associated diseases and disorders

CCR6 has links to conditions such as autoimmune diseases with rheumatoid arthritis and inflammatory bowel disease being notable examples. In rheumatoid arthritis the dysregulated expression of CCR6 attracts Th17 cells into synovial tissues promoting inflammation. Meanwhile inflammatory bowel disease shows a similar pattern of CCR6-mediated chemotaxis that encourages Th17 cell recruitment. In these contexts CCR6 cooperates with other immune mediators like CCL20 to perpetuate disease-related inflammatory processes highlighting its potential as a therapeutic target in immune modulation.