AB191575

Anti-CCR7/CD197 antibody

Name: Anti-CCR7/CD197 antibody (ab191575) | Abcam
Brand: Abcam Limited
SKU: AB191575

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(9 Publications )

Rabbit Polyclonal CCR7 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human CCR7/CD197.

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR7/CD197 antibody (AB191575)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR7/CD197 antibody (AB191575)

Immunohistochemical analysis of paraffin-embedded Human spleen tissue labeling CCR7 with ab191575 at 20 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR7/CD197 antibody (AB191575)

Immunohistochemical analysis of paraffin-embedded Human spleen tissue labeling CCR7 with ab191575 at 5 μg/ml.

Supplier Data

Western blot - Anti-CCR7/CD197 antibody (AB191575)

All lanes:

Western blot - Anti-CCR7/CD197 antibody (ab191575) at 1 µg/mL

All lanes:

Human spleen tissue lysate at 15 µg

Predicted band size: 43 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CCR7/CD197. The exact immunogen used to generate this antibody is proprietary information.

P32248

Specificity

ab191575 is predicted to not cross-react with other CCR proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCR7 also known as CD197 is a chemokine receptor with a molecular mass of approximately 43-48 kDa. The receptor is known to be expressed predominantly in lymphoid tissues such as the spleen and lymph nodes. Additionally CCR7 is found on various immune cells like T cells and dendritic cells. Researchers study CCR7 using different methods such as CCR7-PE and CCR7-APC antibody staining in flow cytometry to examine its expression on immune cells in various conditions.

Biological function summary

CCR7 plays an important role in directing the migration and homeostasis of T cells and dendritic cells. It is not part of a larger protein complex but interacts functionally with specific signaling enzymes upon activation. CCR7 is important for the function of the immune system aiding in the development of adaptive immunity by controlling lymphocyte movement and positioning in lymphoid tissues. This receptor assists in guiding cells to specific lymphoid organs where immune responses are initiated and maintained.

Pathways

CCR7 is significantly involved in the CCL19/CCL21 chemokine signaling pathways which help direct immune cell positioning. CCR7 interacts with these chemokines to regulate the trafficking of cells to lymphoid tissues. Additionally it works in tandem with other receptors like CCR5 in the regulation of immune cell mobilization. These pathways are essential in coordinating the immune response during infection and inflammation.

CCR7 is connected with cancer metastasis and chronic inflammatory diseases. Its role in cell migration makes it relevant in the metastasis of certain cancers where cells misregulate their movement and spread from the original tumor site. Additionally CCR7's involvement in chronic inflammatory diseases highlights its connection to rheumatoid arthritis where it may interact with other proteins such as CCL19 and CCL21 contributing to disease progression. Understanding these interactions helps develop potential therapeutic strategies targeting CCR7 in such diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

See full target information CCR7/CD197

Alternative Names

CD197, CMKBR7, EBI1, EVI1, CCR7, C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, BLR2, CDw197, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, EBV-induced G-protein coupled receptor 1

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Publications (9)

Recent publications for all applications. Explore the full listand refine your search

Oncology research 33:199-212 PubMed39735670

2024

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Yang,Bin Tang,Dan Xu,Wenxiu Yang

Cancer control : journal of the Moffitt Cancer Center 31:10732748241238616 PubMed38553809

2024

CCL21 and CLDN11 Are Key Driving Factors of Lymph Node Metastasis in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shaofei Yang,Dandan Dong,Xunxia Bao,Rongting Lu,Pufei Cheng,Sibo Zhu,Guanghua Yang

Bioengineering & translational medicine 8:e10528 PubMed37476066

2023

Plasma-activated medium triggers immunomodulation and autophagic activity for periodontal regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Shengfang Wang,Peiyu Wang,Rik Thompson,Kostya Ostrikov,Yin Xiao,Yinghong Zhou

PeerJ 11:e14929 PubMed36846458

2023

The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Jing-Lu Li,Gui-Qiang Fu,Yang-Yang Wang,Ming-Ming Bian,Yao-Mei Xu,Lin Zhang,Yu-Qing Chen,Nan Zhang,Shu-Qin Ding,Rui Wang,Rui Fang,Jie Tang,Jian-Guo Hu,He-Zuo Lü

Neural regeneration research 16:1836-1847 PubMed33510091

2021

VX-765 reduces neuroinflammation after spinal cord injury in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Chen,Yu-Qing Chen,Yu-Jiao Shi,Shu-Qin Ding,Lin Shen,Rui Wang,Qi-Yi Wang,Cheng Zha,Hai Ding,Jian-Guo Hu,He-Zuo Lü

Journal of neuroinflammation 17:255 PubMed32861243

2020

CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Qing Chen,Sai-Nan Wang,Yu-Jiao Shi,Jing Chen,Shu-Qin Ding,Jie Tang,Lin Shen,Rui Wang,Hai Ding,Jian-Guo Hu,He-Zuo Lü

Acta biomaterialia 97:187-199 PubMed31386930

2019

Eluted 25-hydroxyvitamin D from radially aligned nanofiber scaffolds enhances cathelicidin production while reducing inflammatory response in human immune system-engrafted mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shixuan Chen,Liangpeng Ge,Hongjun Wang,Yan Cheng,Santhi Gorantla,Larisa Y Poluektova,Adrian F Gombart,Jingwei Xie

Journal of cellular physiology 234:13145-13156 PubMed30584667

2018

The effects of CCR7 and related signaling pathways on Leishmania major -infected human dendritic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yumin Zhao,Zhisheng Dang,Riming Wei,Weifeng Gui,Yishu Zhang,Shigui Chong

Journal of the American Heart Association 4: PubMed25814626

2015

A change in inflammatory footprint precedes plaque instability: a systematic evaluation of cellular aspects of the adaptive immune response in human atherosclerosis.

Applications

IHC-P

Species

Human

R A van Dijk,A J F Duinisveld,A F Schaapherder,A Mulder-Stapel,J F Hamming,J Kuiper,O J de Boer,A C van der Wal,F D Kolodgie,R Virmani,J H N Lindeman

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCR7/CD197 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR7/CD197 antibody (AB191575)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR7/CD197 antibody (AB191575)

Western blot - Anti-CCR7/CD197 antibody (AB191575)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Alternative Products

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Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Alternative Names

Publications (9)

Product promise