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AB8019

Anti-CCR8 antibody

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(3 Publications)

Rabbit Polyclonal CCR8 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CCR8 aa 150-250.

View Alternative Names

CDw198, CKRL1, CMKBR8, CMKBRL2, CCR8, C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, Chemokine receptor-like 1, GPR-CY6, TER1, CKR-L1, GPRCY6

1 Images
Western blot - Anti-CCR8 antibody (AB8019)
  • WB

Unknown

Western blot - Anti-CCR8 antibody (AB8019)

All lanes:

Western blot - Anti-CCR8 antibody (ab8019) at 1/500 dilution

All lanes:

human spleen lysate

Predicted band size: 41 kDa

Observed band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CCR8 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

P51685

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CC chemokine receptor 8 abbreviated as CCR8 is a G protein-coupled receptor with an approximate molecular mass of 41 kDa. It is also known as CDw198. Expression of CCR8 protein is observed mainly in T cells particularly CD4+ T cells and natural killer cells. Antibody against CCR8 like anti-CCR8 can be used to study the expression of this receptor in tissues via immunohistochemistry (IHC) which may be referred to as CCR8 IHC.
Biological function summary

CCR8 plays a role in immune cell signaling and migration. This receptor interacts with its ligand CCL1 to mediate chemotaxis guiding cells to sites of inflammation or injury. CCR8 forms a part of the immune response machinery facilitating communication between cells. Through these interactions it influences the function of various immune cells such as regulatory T cells and supports the maintenance of immune homeostasis.

Pathways

CCR8 is involved in chemokine signaling pathways that regulate immune responses. It operates within the broader context of the chemokine receptor family including receptors like CCR4. These pathways are important for directing lymphocyte migration and are implicated in inflammation and immune surveillance processes. The engagement of CCR8 modulates downstream signaling events that influence T cell differentiation and immune cell recruitment.

Alterations in CCR8 expression or function relate to inflammatory diseases and certain cancers. Aberrant expression of CCR8 associates with disorders such as autoimmune diseases and Hodgkin's lymphoma. In cancer the cross-talk between CCR8 and its ligands can promote a protumorigenic environment aiding tumor progression. Connections exist between CCR8 and other receptors like CCR4 in these pathologies highlighting its role in disease development and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
See full target information CCR8
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 17:113-128 PubMed38384996

2024

Exosome-Delivered EGFR Induced by Acidic Bile Salts Regulates Macrophage M2 Polarization to Promote Esophageal Adenocarcinoma Cell Proliferation.

Applications

Unspecified application

Species

Unspecified reactive species

Chuangui Chen,Jinsheng Ding,Zhao Ma,Yongjie Xie,Linhua Zhang,Dunwan Zhu

The American journal of pathology 191:686-703 PubMed33460563

2021

Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Masataka Fujikawa,Yu-Ichiro Koma,Masayoshi Hosono,Naoki Urakawa,Kohei Tanigawa,Masaki Shimizu,Takayuki Kodama,Hiroki Sakamoto,Mari Nishio,Manabu Shigeoka,Yoshihiro Kakeji,Hiroshi Yokozaki

European journal of medical research 22:40 PubMed29020986

2017

Colorectal cancer-infiltrating T lymphocytes display a distinct chemokine receptor expression profile.

Applications

Flow Cyt

Species

Human

Ann-Britt Löfroos,Mohammad Kadivar,Sabina Resic Lindehammer,Jan Marsal
View all publications
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