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AB235002

Anti-CCRL2 antibody

4

(1 Review)

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(1 Publication)

Rabbit Polyclonal CCRL2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CCRL2 aa 1-50.

View Alternative Names

CCR11, CCR6, CKRX, CRAM, HCR, CCRL2, C-C chemokine receptor-like 2, Chemokine receptor CCR11, Chemokine receptor X, Putative MCP-1 chemokine receptor

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCRL2 antibody (AB235002)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCRL2 antibody (AB235002)

Paraffin-embedded human kidney tissue stained for CCRL2 using ab235002 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-CCRL2 antibody (AB235002)
  • WB

Supplier Data

Western blot - Anti-CCRL2 antibody (AB235002)

All lanes:

Western blot - Anti-CCRL2 antibody (ab235002) at 1/500 dilution

All lanes:

HL-60 (Human promyelocytic leukemia cell line) cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CCRL2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O00421

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CCRL2 protein also known as CC chemokine receptor-like 2 belongs to the seven-transmembrane domain receptor family. This is a smaller GPCR with an approximate mass of 39 kDa. It does not bind ligands like traditional chemokine receptors but acts more like a decoy. Scientists have found its expression primarily on immune cells including monocytes and macrophages as well as on some endothelial and epithelial cells. The expression can vary depending on the activation state of the cells or tissue type.
Biological function summary

CCRL2 influences immune cell homeostasis and response. It does not function in the same way as classical ligand-binding chemokine receptors but serves as a scavenger or "silent" receptor. This characteristic allows it to sequester ligand availability shaping the local chemokine gradient. Researchers see its activity as closely linked to the regulation of immune responses and inflammation although they haven't fully clarified its role in immune signaling complexes.

Pathways

Scientists see CCRL2 as integral to inflammatory responses and chemotactic pathways. It maintains connections to the CXCR3 and CCR5 pathways systems essential for directing immune cell migration. These interactions help moderate the immune system's response intensity. Investigators have found that CCRL2 influences related proteins such as chemerin contributing to chemokine signaling network modulation.

Researchers associate CCRL2 with inflammatory conditions and cancer. Its atypical receptor function affects the immune landscape in the tumor microenvironment suggesting a role in regulating immune evasion by tumors. Additionally CCRL2 interacts with chemerin in inflammatory diseases impacting conditions like rheumatoid arthritis by potentially controlling inflammatory cell recruitment. This makes CCRL2 an interesting target for therapies aimed at modulating immune system activities in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
See full target information CCRL2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:29643 PubMed40804093

2025

miR-221 activates Sox11 to reduce brain injury after intracerebral hemorrhage via inhibiting neuroinflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Tianyu Liang,Yongchun Liu,Renyang Liu,Xianmei Shen,Mingxia Xu
View all publications
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Product promise

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