AB110905

Anti-CCT6A antibody

Name: Anti-CCT6A antibody (ab110905) | Abcam
Brand: Abcam Limited
SKU: AB110905
Price: 470 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal CCT6A antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CCT6A.

View Alternative Names

CCT6, CCTZ, CCT6A, T-complex protein 1 subunit zeta, TCP-1-zeta, Acute morphine dependence-related protein 2, CCT-zeta-1, Chaperonin containing T-complex polypeptide 1 subunit 6A, HTR3, Tcp20

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCT6A antibody (AB110905)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCT6A antibody (AB110905)

ab110905, at a 1/50 dilution, staining CCT6A in paraffin embedded Human breast carcinoma tissue by Immunohistochemistry. The image on the right is from tissue treated with the synthesized peptide.

Unknown

Western blot - Anti-CCT6A antibody (AB110905)

All lanes:

Western blot - Anti-CCT6A antibody (ab110905) at 1/500 dilution

Lane 1:

HepG2 cell extracts at 30 µg

Lane 2:

HepG2 cell extracts at 30 µg with immunizing peptide

Predicted band size: 58 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human CCT6A. The exact immunogen used to generate this antibody is proprietary information.

P40227

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab110905 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49.1% PBS, 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCT6A also known as TCP-1-zeta or CCT-zeta acts as a component of the chaperonin-containing TCP-1 complex with a mass approximately 60 kDa. This complex facilitates protein folding in an ATP-dependent manner. Predominantly researchers find CCT6A in the cytoplasm of eukaryotic cells and it expresses in various tissues indicating its broad functional role.

Biological function summary

CCT6A plays an important role in folding newly synthesized proteins and refolding denatured proteins. It is a part of the essential chaperonin complex that consists of eight different subunits including CCT6A which collaborates to ensure correct protein conformation. This function supports cellular proteostasis maintaining the balance and health of the proteome which is critical for proper cell function and survival.

Pathways

CCT6A participates in the protein folding pathway and interacts with the protein catabolic processes. It plays an important part in pathways such as cytosolic protein folding and folding of actin and tubulin. Through these pathways CCT6A associates with proteins like HSP70 which also contributes to protein folding and stability signifying shared roles in maintaining cell homeostasis.

CCT6A's involvement impacts various neurodegenerative conditions and cancer. Misfolded proteins that are not adequately managed by chaperonin complexes including CCT6A are linked to diseases like Alzheimer's. In cancer the misregulation of protein folding pathways involving CCT6A might contribute to tumorigenesis. CCT6A holds connections with proteins such as p53 where impaired folding of tumor suppressors can lead to oncogenic outcomes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed : 25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed : 25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable).

See full target information CCT6A

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical laboratory analysis 36:e24609 PubMed35838025

2022

The intercorrelation among CCT6A, CDC20, CCNB1, and PLK1 expressions and their clinical value in papillary thyroid carcinoma prognostication.

Applications

IHC

Species

Human

Wei Peng,Wenqiang Li,Xiaoyong Zhang,Weili Cen,Yanan Liu

Molecular medicine reports 25: PubMed35315492

2022

HOXB2 increases the proliferation and invasiveness of colon cancer cells through the upregulation of CCT6A.

Applications

Unspecified application

Species

Unspecified reactive species

Xuelian Yang,Yuanhe Tong,Wenxia Ye,Lifen Chen

Cell death & disease 10:644 PubMed31501420

2019

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ya Liu,Xiao Zhang,Jiafei Lin,Yuxin Chen,Yongxia Qiao,Susu Guo,Yueyue Yang,Guoqing Zhu,Qiuhui Pan,Jiayi Wang,Fenyong Sun

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCT6A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCT6A antibody (AB110905)

Western blot - Anti-CCT6A antibody (AB110905)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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