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AB24986

Anti-CD1 antibody [76-7-4]

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(1 Publication)

Mouse Monoclonal CD1A antibody. Suitable for Flow Cyt and reacts with Pig samples. Cited in 1 publication.

View Alternative Names

CD1a, CD1.1, CD1A, T-cell surface glycoprotein CD1a

1 Images
Flow Cytometry - Anti-CD1 antibody [76-7-4] (AB24986)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD1 antibody [76-7-4] (AB24986)

Flow cytometry analysis of porcine peripheral blood lymphocytes labeling CD1 with ab24986 followed by Goat Anti-Mouse IgG2a, Human ads-FITC.

  • 578 PE

    PE Anti-CD1 antibody [76-7-4]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

76-7-4

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Pig

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Pig": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>" } } }
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Product details

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 8.2 Constituents: 100% Borate buffered saline
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CD1 group of glycoproteins are involved in immune response. Also known as cluster of differentiation 1 the CD1 molecules have multiple isoforms including CD1a CD1b CD1c CD1d and CD1e. CD1 proteins have a molecular mass ranging from 43 to 49 kDa. These proteins are expressed on the surface of antigen-presenting cells like dendritic cells B cells and some types of T cells. CD1 molecules structurally resemble MHC class I molecules but function differently by presenting lipid and glycolipid antigens to T cells.
Biological function summary

CD1 proteins play a role in the immune system by presenting lipid antigens to T cells. This antigen presentation aids in the activation of T cells particularly Natural Killer T (NKT) cells. CD1 molecules participate as part of a complex with β2-microglobulin which stabilizes the CD1 structure and facilitates antigen delivery to the cell surface. The presence of CD1 on antigen-presenting cells ensures that a broad range of lipid antigens can be sampled integrating important functions in both innate and adaptive immunity.

Pathways

CD1 proteins are important in adaptive immune system pathways. They take part in pathogen recognition and immune response pathways where they work together with pattern recognition receptors and T-cell receptors. These proteins possess similarities with MHC molecules engaging in parallel pathways of antigen processing and presentation. Their activity is intertwined with proteins like CD3 and the T-cell receptor complex; they facilitate communication and response initiation in T cells.

CD1 proteins have implications in autoimmunity and infectious diseases. CD1 molecules are involved in the recognition of mycobacterial lipids which is relevant to diseases like tuberculosis where an immune response is important. The proteins also relate to autoimmune diseases as dysregulation may lead to improper immune cell activation. Researchers are investigating links between CD1 and inflammatory diseases where molecules like CD1d interact with CD1-restricted NKT cells highlighting CD1’s role in modulating immune responses in health and disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
See full target information CD1A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Pathogens (Basel, Switzerland) 6: PubMed28327531

2017

Porcine Dendritic Cells as an In Vitro Model to Assess the Immunological Behaviour of Streptococcus suis Subunit Vaccine Formulations and the Polarizing Effect of Adjuvants.

Applications

Unspecified application

Species

Unspecified reactive species

Léa Martelet,Sonia Lacouture,Guillaume Goyette-Desjardins,Guy Beauchamp,Charles Surprenant,Marcelo Gottschalk,Mariela Segura
View all publications
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Product promise

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