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AB239734

Anti-CD105 antibody [17#]

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(1 Publication)

Mouse Monoclonal Eng protein antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication.
2 Images
Western blot - Anti-CD105 antibody [17#] (AB239734)
  • WB

Supplier Data

Western blot - Anti-CD105 antibody [17#] (AB239734)

All lanes:

Western blot - Anti-CD105 antibody [17#] (ab239734) at 2 µg/mL

All lanes:

Recombinant rat CD105 protein

Predicted band size: 70 kDa

false

Western blot - Anti-CD105 antibody [17#] (AB239734)
  • WB

Supplier Data

Western blot - Anti-CD105 antibody [17#] (AB239734)

All lanes:

Western blot - Anti-CD105 antibody [17#] (ab239734) at 3 µg/mL

All lanes:

Human lung tissue lysate

Secondary

All lanes:

HRP-Goat Anti-Mouse IgG at 0.2 µg/mL

Predicted band size: 70 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

17#

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human, Rat

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography. Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.
Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Eng protein
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Pharmaceutics 14: PubMed36297644

2022

Autologous Genetically Enriched Leucoconcentrate in the Preventive and Acute Phases of Stroke Treatment in a Mini-Pig Model.

Applications

Unspecified application

Species

Unspecified reactive species

Zufar Safiullov,Andrei Izmailov,Mikhail Sokolov,Vage Markosyan,Grayr Kundakchan,Ravil Garifulin,Maksim Shmarov,Boris Naroditsky,Denis Logunov,Rustem Islamov
View all publications
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Product promise

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