AB231673

Anti-CD105 antibody

Name: Anti-CD105 antibody (ab231673) | Abcam
Brand: Abcam Limited
SKU: AB231673
Price: 525 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal Endoglin antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 3 publications.

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8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody (AB231673)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody (AB231673)

Formalin-fixed, paraffin-embedded rat skeletal muscle tissue stained for CD105 using ab231673 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody (AB231673)

Formalin-fixed, paraffin-embedded rat lung tissue stained for CD105 using ab231673 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody (AB231673)

Formalin-fixed, paraffin-embedded rat stomach tissue stained for CD105 using ab231673 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody (AB231673)

Formalin-fixed, paraffin-embedded rat kidney tissue stained for CD105 using ab231673 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody (AB231673)

Formalin-fixed, paraffin-embedded rat spinal cord tissue stained for CD105 using ab231673 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody (AB231673)

Formalin-fixed, paraffin-embedded rat colon tissue stained for CD105 using ab231673 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-CD105 antibody (AB231673)

All lanes:

Western blot - Anti-CD105 antibody (ab231673) at 1 µg/mL

Lane 1:

Rat serum

Lane 2:

Rat kidney lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 70 kDa

false

Supplier Data

Western blot - Anti-CD105 antibody (AB231673)

All lanes:

Western blot - Anti-CD105 antibody (ab231673) at 1 µg/mL

All lanes:

Recombinant rat CD105 protein

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 70 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

WB, IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.

Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Endoglin

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Bone & joint research 12:615-623 PubMed37783468

2023

Regeneration of injured articular cartilage using the recombinant human amelogenin protein.

Applications

Unspecified application

Species

Unspecified reactive species

Omer Helwa-Shalom,Faris Saba,Elad Spitzer,Salem Hanhan,Koby Goren,Shany I Markowitz,Dekel Shilo,Nissim Khaimov,Yechiel N Gellman,Dan Deutsch,Anat Blumenfeld,Hani Nevo,Amir Haze

Journal of veterinary research 67:307-314 PubMed38143820

2023

Functional and morphological maturation of the full-sized and mini-pig corpus luteum by programmed cell death mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Ji-Hye Lee,Sang-Hwan Kim

Biomaterials research 24:17 PubMed33014414

2020

In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds.

Applications

Unspecified application

Species

Unspecified reactive species

Naghmeh Abbasi,Ryan S B Lee,Saso Ivanovski,Robert M Love,Stephen Hamlet

View all publications

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