AB11414

Anti-CD105 antibody [SN6]

Name: Anti-CD105 antibody [SN6] (ab11414) | Abcam
Brand: Abcam Limited
SKU: AB11414
Price: 620 USD
Availability: InStock
Rating: 5 (6 reviews)

(6 Reviews)

(85 Publications)

Mouse Monoclonal CD105 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 85 publications. Immunogen corresponding to Synthetic Peptide within Human ENG.

View Alternative Names

CD105, END, ENG, Endoglin

1 Images

Flow Cytometry - Anti-CD105 antibody [SN6] (AB11414)

Flow Cyt

Unknown

Flow Cytometry - Anti-CD105 antibody [SN6] (AB11414)

ab11414 staining CD105 in human KG1 cells by Flow Cytometry analysis.

519 FITC

FITC Anti-CD105 antibody [SN6]
660 APC

APC Anti-CD105 antibody [SN6]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SN6

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Synthetic Peptide within Human ENG. The exact immunogen used to generate this antibody is proprietary information.

P17813

Specificity

ab11414 recognises the human CD105 cell surface antigen.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "Use 10µl of the neat dilution to label 106 cells in 100µl.<a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "CD105 is a glycoprotein homodimer of 95kD subunits." } } }

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Product details

This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified IgG prepared by affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.

Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed : 21737454, PubMed : 23300529). Required for normal structure and integrity of adult vasculature (PubMed : 7894484). Regulates the migration of vascular endothelial cells (PubMed : 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed : 1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529, PubMed : 8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529).

See full target information ENG

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Publications (85)

Recent publications for all applications. Explore the full list and refine your search

Cell proliferation 58:e13756 PubMed39358887

2024

KDM2B and its peptides promote the stem cells from apical papilla mediated nerve injury repair in rats by intervening EZH2 function.

Applications

Unspecified application

Species

Unspecified reactive species

Yangyang Cao,Yantong Wang,Dengsheng Xia,Zhipeng Fan

European journal of clinical investigation 54:e14212 PubMed38591651

2024

Elevated circulating BMP9 aggravates pulmonary angiogenesis in hepatopulmonary syndrome rats through ALK1-Endoglin-Smad1/5/9 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Chunyong Yang,Mei Sun,Yihui Yang,Yan Han,Xiulin Wu,Xianfeng Wu,Huilin Cao,Lin Chen,Yuhao Lei,Xiaoyan Hu,Yang Chen,Ziyang Zeng,Junhong Li,Xin Shu,Zhiyong Yang,Kaizhi Lu,Yujie Li,Xiaobo Wang,Bin Yi

Breast cancer research : BCR 26:11 PubMed38229104

2024

Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Mikkel Morsing Bagger,Jonas Sjölund,Jiyoung Kim,Katharina Theresa Kohler,René Villadsen,Abbas Jafari,Moustapha Kassem,Kristian Pietras,Lone Rønnov-Jessen,Ole William Petersen

International journal of oral science 15:48 PubMed37852994

2023

MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Zhang,Weilong Ye,Mengyao Zhao,Lujue Long,Dengsheng Xia,Zhipeng Fan

Frontiers in cell and developmental biology 11:1219739 PubMed37799276

2023

Self-assembled adipose-derived mesenchymal stem cells as an extracellular matrix component- and growth factor-enriched filler.

Applications

Unspecified application

Species

Unspecified reactive species

Choa Park,Ok-Hee Lee,Jin Ju Park,Jiyoon Yoo,Euna Kwon,Jie-Eun Park,Byeong-Cheol Kang,Dong-Sup Lee,Jaejin Cho

JACC. Basic to translational science 8:1081-1097 PubMed37791312

2023

Empagliflozin Suppresses the Differentiation/Maturation of Human Epicardial Preadipocytes and Improves Paracrine Secretome Profile.

Applications

Unspecified application

Species

Unspecified reactive species

Masayuki Takano,Hidekazu Kondo,Taisuke Harada,Masaki Takahashi,Yumi Ishii,Hirochika Yamasaki,Tong Shan,Kumiko Akiyoshi,Takashi Shuto,Yasushi Teshima,Tomoyuki Wada,Kunio Yufu,Hidenori Sako,Hirofumi Anai,Shinji Miyamoto,Naohiko Takahashi

Brain and behavior 13:e3043 PubMed37165750

2023

Combined treatment of high-intensity interval training with neural stem cell generation on contusive model of spinal cord injury in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Reza Keikhaei,Elahe Abdi,Marzieh Darvishi,Zohreh Ghotbeddin,Hatef Ghasemi Hamidabadi

Communications biology 6:476 PubMed37127734

2023

Definitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yumeng Zhang,Ye Yi,Xia Xiao,Lingling Hu,Jiaqi Xu,Dejin Zheng,Ho Cheng Koc,Un In Chan,Ya Meng,Ligong Lu,Weiwei Liu,Xiaoling Xu,Ningyi Shao,Edwin Chong Wing Cheung,Ren-He Xu,Guokai Chen

Stem cell research & therapy 14:47 PubMed36941706

2023

Residual periodontal ligament in the extraction socket promotes the dentin regeneration potential of DPSCs in the rabbit jaw.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Luo,Yu Luo,Lin He,Yangyang Cao,Qingsong Jiang

Stem cells international 2022:2164057 PubMed36311041

2022

miR-31 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviates Intervertebral Disc Degeneration by Inhibiting NFAT5 and Upregulating the Wnt/-Catenin Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Baodong Wang,Na Xu,Li Cao,Xiaojun Yu,Shanxi Wang,Qikun Liu,Yinguang Wang,Haoran Xu,Yang Cao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD105 antibody [SN6]

Flow Cytometry - Anti-CD105 antibody [SN6] (AB11414)

Related conjugates and formulations (2)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (85)

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