Anti-CD11b antibody [ITGAM/3338]
- Lab Essentials
- What is this?
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(1 Publication)
Mouse Monoclonal CD11b antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ITGAM aa 900-1100.
View Alternative Names
CD11b, CD11B, CR3A, ITGAM, Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11b antibody [ITGAM/3338] (AB269676)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for CD11b using ab269676 at 2 μg/ml in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11b antibody [ITGAM/3338] (AB269676)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for CD11b using ab269676 at 2 μg/ml in immunohistochemical analysis.
- Protein Array
Characteriser
Protein Array - Anti-CD11b antibody [ITGAM/3338] (AB269676)
Analysis of Protein Array containing more than 19,000 full-length human proteins using ab269676.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
- WB
Supplier Data
Western blot - Anti-CD11b antibody [ITGAM/3338] (AB269676)
All lanes:
Western blot - Anti-CD11b antibody [ITGAM/3338] (ab269676) at 2 µg/mL
All lanes:
Human spleen lysate
Predicted band size: 127 kDa
false
Reactivity data
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CD11b plays a critical role in various immune responses by mediating phagocytosis chemotaxis and cell migration. It is essential for proper leukocyte adherence to endothelial cells and for the engulfment of pathogens or apoptotic cells. CD11b as part of the Mac-1 complex contributes to the immune surveillance and inflammatory processes. This complex interacts with diverse ligands like ICAM-1 fibrinogen and complement component iC3b facilitating an immunological response.
Pathways
CD11b is instrumental within the integrin signaling pathway and the Leukocyte Transendothelial Migration pathway. Its interaction with ICAM-1 is central to the leukocyte adhesion cascade influencing the movement of immune cells across endothelial barriers. CD11b also associates with proteins such as Src family kinases and PI3K which activate downstream signaling responsible for the reorganization of the cytoskeleton and cell movement during immune responses.
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Target data
Publications (1)
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Gynecologic oncology reports 59:101758 PubMed40487855
2025
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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