AB216028

Anti-CD11c antibody [ITGAX/1242]

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(2 Publications)

Mouse Monoclonal CD11c antibody. Suitable for Protein Array, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ITGAX aa 600-850.

View Alternative Names

CD11c, CD11C, ITGAX, Integrin alpha-X, CD11 antigen-like family member C, Leu M5

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [ITGAX/1242] (AB216028)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [ITGAX/1242] (AB216028)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human tonsil tissue labeling CD11c with ab216028 at 1 μg/mL, followed by ABC detection with DAB Chromogen.

Protein Array - Anti-CD11c antibody [ITGAX/1242] (AB216028)

Protein Array

Unknown

Protein Array - Anti-CD11c antibody [ITGAX/1242] (AB216028)

ab216028 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ITGAX/1242

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

Protein Array, IHC-P

Immunogen

Recombinant Fragment Protein within Human ITGAX aa 600-850. The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Purification notes

ab216028 is purified from Bioreactor Concentrate by Protein A/G.

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.

Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed : 16985175).

See full target information ITGAX

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:2539 PubMed35534483

2022

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Qiao,Hui En Lau,Huizhi Xie,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Hin Chu,Shuofeng Yuan,Terrence Tsz-Tai Yuen,Kenn Ka-Heng Chik,Jessica Oi-Ling Tsang,Chris Chun-Yiu Chan,Jian-Piao Cai,Cuiting Luo,Kwok-Yung Yuen,Kenneth Man-Chee Cheung,Jasper Fuk-Woo Chan,Kelvin Wai-Kwok Yeung

The Journal of experimental medicine 218: PubMed33779682

2021

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.

Applications

Unspecified application

Species

Unspecified reactive species

Frank M Davis,Lam C Tsoi,William J Melvin,Aaron denDekker,Rachael Wasikowski,Amrita D Joshi,Sonya Wolf,Andrea T Obi,Allison C Billi,Xianying Xing,Christopher Audu,Bethany B Moore,Steven L Kunkel,Alan Daugherty,Hong S Lu,Johann E Gudjonsson,Katherine A Gallagher

View all publications

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Product promise

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