AB215858

Anti-CD11c antibody [ITGAX/1243]

Name: Anti-CD11c antibody [ITGAX/1243] (ab215858) | Abcam
Brand: Abcam Limited
SKU: AB215858
Price: 510 USD
Availability: InStock

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(4 Publications)

Mouse Monoclonal CD11c antibody. Suitable for Protein Array and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ITGAX aa 600-850.

View Alternative Names

CD11c, CD11C, ITGAX, Integrin alpha-X, CD11 antigen-like family member C, Leu M5

1 Images

Protein Array - Anti-CD11c antibody [ITGAX/1243] (AB215858)

Protein Array

Unknown

Protein Array - Anti-CD11c antibody [ITGAX/1243] (AB215858)

ab215858 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ITGAX/1243

Isotype

IgG2b

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

Protein Array

applications

Immunogen

Recombinant Fragment Protein within Human ITGAX aa 600-850. The exact immunogen used to generate this antibody is proprietary information.

P20702

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.

Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

See full target information ITGAX

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:3359 PubMed37291192

2023

Pluripotency-independent induction of human trophoblast stem cells from fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Moriyah Naama,Moran Rahamim,Valery Zayat,Shulamit Sebban,Ahmed Radwan,Dana Orzech,Rachel Lasry,Annael Ifrah,Mohammad Jaber,Ofra Sabag,Hazar Yassen,Areej Khatib,Silvina Epsztejn-Litman,Michal Novoselsky-Persky,Kirill Makedonski,Noy Deri,Debra Goldman-Wohl,Howard Cedar,Simcha Yagel,Rachel Eiges,Yosef Buganim

Cancer science 114:1846-1858 PubMed36748311

2023

Prognostic relevance of tumor-resident memory T cells in metastatic lymph nodes of esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Seiji Natsuki,Hiroaki Tanaka,Masaki Nishiyama,Takuya Mori,Sota Deguchi,Yuichiro Miki,Mami Yoshii,Tatsuro Tamura,Takahiro Toyokawa,Shigeru Lee,Kiyoshi Maeda

iScience 25:104602 PubMed35789845

2022

Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures.

Applications

Unspecified application

Species

Unspecified reactive species

Matúš Soták,Meenu Rohini Rajan,Madison Clark,Matthew Harms,Alankrita Rani,Jamie D Kraft,David Tandio,Tong Shen,Kamil Borkowski,Oliver Fiehn,John W Newman,Marianne Quiding-Järbrink,Christina Biörserud,Peter Apelgren,Trude Staalesen,Carolina E Hagberg,Jeremie Boucher,Ville Wallenius,Stephan Lange,Emma Börgeson

Cancer science 112:1746-1757 PubMed33735485

2021

Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Takuya Mori,Hiroaki Tanaka,Shugo Suzuki,Sota Deguchi,Yoshihito Yamakoshi,Mami Yoshii,Yuichiro Miki,Tatsuro Tamura,Takahiro Toyokawa,Shigeru Lee,Kazuya Muguruma,Hideki Wanibuchi,Masaichi Ohira

View all publications

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