AB185783

Anti-CD11c antibody [N418] - Low endotoxin, Azide free

Name: Anti-CD11c antibody [N418] - Low endotoxin, Azide free (ab185783) | Abcam
Brand: Abcam Limited
SKU: AB185783

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(2 Publications )

Armenian hamster Monoclonal CD11c antibody. Carrier free. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 2 publications.

View Alternative Names

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax

1 Images

Flow Cytometry - Anti-CD11c antibody [N418] - Low endotoxin, Azide free (AB185783)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD11c antibody [N418] - Low endotoxin, Azide free (AB185783)

Flow cytometric analysis of mouse C57BI/6 splenocytes with an anti-Human/mouse CD45R antibody and 0.5 μg of armenian hamster IgG Isotype Control (left) or 0.5 μg of ab185783 (right) followed by anti-armenian hamster IgG FITC. Cells in the lymphocyte gate were used for analysis.

Unconjugated

Anti-CD11c antibody [N418]
Carrier free

Anti-CD11c antibody [N418] - BSA and Azide free
660 APC

APC Anti-CD11c antibody [N418]
785 APC/Cy7®

APC/Cy7® Anti-CD11c antibody [N418]
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-CD11c antibody [N418]
665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-CD11c antibody [N418]
Biotin

Biotin Anti-CD11c antibody [N418]
519 FITC

FITC Anti-CD11c antibody [N418]
578 PE

PE Anti-CD11c antibody [N418]
667 PE/Cy5®

PE/Cy5® Anti-CD11c antibody [N418]
778 PE/Cy7®

PE/Cy7® Anti-CD11c antibody [N418]
695 PerCP/Cy5.5®

PerCP/Cy5.5® Anti-CD11c antibody [N418]
450 violetFluor™ 450

violetFluor™ 450 Anti-CD11c antibody [N418]

Key facts

Host species

Armenian hamster

Clonality

Monoclonal

Clone number

N418

Isotype

IgG

Carrier free

Yes

Reacts with

Mouse

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p>In a final volume of 100 μL.</p><p><a href='/en-us/products/primary-antibodies/armenian-hamster-igg-monoclonal-htk888-isotype-control-ab18479'>ab18479</a> - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>" } } }

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Product details

Endotoxin Level: Less than 0.001 ng/ug antibody, as determined by the LAL assay.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.2

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.

Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis.

See full target information Itgax

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107293 PubMed37520709

2023

GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Daisuke Tsukui,Yoshitaka Kimura,Hajime Kono

Angiogenesis 26:505-522 PubMed37120604

2023

Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques.

Applications

Unspecified application

Species

Unspecified reactive species

Pauline Puylaert,Lynn Roth,Melissa Van Praet,Isabel Pintelon,Catalina Dumitrascu,Alexander van Nuijs,Greta Klejborowska,Pieter-Jan Guns,Tom Vanden Berghe,Koen Augustyns,Guido R Y De Meyer,Wim Martinet

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD11c antibody [N418] - Low endotoxin, Azide free

Flow Cytometry - Anti-CD11c antibody [N418] - Low endotoxin, Azide free (AB185783)

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Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise