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AB185783

Anti-CD11c antibody [N418] - Low endotoxin, Azide free

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Armenian hamster Monoclonal CD11c antibody. Carrier free. Suitable for Flow Cyt and reacts with Mouse samples.

View Alternative Names

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax

1 Images
Flow Cytometry - Anti-CD11c antibody [N418] - Low endotoxin, Azide free (AB185783)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD11c antibody [N418] - Low endotoxin, Azide free (AB185783)

Flow cytometric analysis of mouse C57BI/6 splenocytes with an anti-Human/mouse CD45R antibody and 0.5 μg of armenian hamster IgG Isotype Control (left) or 0.5 μg of ab185783 (right) followed by anti-armenian hamster IgG FITC. Cells in the lymphocyte gate were used for analysis.

  • 667 PE/Cy5®

    PE/Cy5® Anti-CD11c antibody [N418]

  • violetFluor™ 450

    violetFluor™ 450 Anti-CD11c antibody [N418]

  • 785 APC/Cy7®

    APC/Cy7® Anti-CD11c antibody [N418]

  • 660 APC

    APC Anti-CD11c antibody [N418]

  • 519 FITC

    FITC Anti-CD11c antibody [N418]

  • 578 PE

    PE Anti-CD11c antibody [N418]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD11c antibody [N418]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-CD11c antibody [N418]

  • Biotin

    Biotin Anti-CD11c antibody [N418]

  • 695 PerCP/Cy5.5®

    PerCP/Cy5.5® Anti-CD11c antibody [N418]

  • Carrier free

    Anti-CD11c antibody [N418] - BSA and Azide free

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-CD11c antibody [N418]

Key facts

Host species

Armenian hamster

Clonality

Monoclonal

Clone number

N418

Isotype

IgG

Carrier free

Yes

Reacts with

Mouse

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p>In a final volume of 100 μL.</p><p><a href='/en-us/products/primary-antibodies/armenian-hamster-igg-monoclonal-htk888-isotype-control-ab18479'>ab18479</a> - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>" } } }
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Product details

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.
Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).
See full target information Itgax
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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