AB196349

Anti-CD11d antibody

Name: Anti-CD11d antibody (ab196349) | Abcam
Brand: Abcam Limited
SKU: AB196349
Price: 520 USD
Availability: InStock
Rating: 1 (1 reviews)

(1 Review)

(1 Publication)

Rabbit Polyclonal CD11d antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ITGAD.

View Alternative Names

CD11d, Integrin alpha-D, ADB2, CD11 antigen-like family member D, Leukointegrin alpha D, ITGAD

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human ITGAD. The exact immunogen used to generate this antibody is proprietary information.

Q13349

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Constituents: 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11d also known as integrin alpha D is a protein that plays a vital role in the adhesion and migration of leukocytes. CD11d forms a heterodimer with CD18 creating the integrin alpha D beta 2 complex. This complex weighs approximately 200 kDa and is expressed mainly on monocytes macrophages and dendritic cells. CD11d is involved in the immune response particularly in the adhesion between cells and the extracellular matrix which facilitates leukocyte trafficking and tissue infiltration.

Biological function summary

CD11d is part of the integrin family a group of proteins that mediate cell surface interactions. It supports the immune surveillance role by allowing immune cells to adhere to and migrate across the vascular endothelium. CD11d is part of the αDβ2 complex which binds to several ligands including ICAM-3 and VCAM-1. This binding is essential for leukocyte migration and establishing immune cell positions during inflammation and immune responses. The protein is expressed more in conditions requiring heightened immune activities or repair.

Pathways

CD11d functions in the leukocyte adhesion cascade and interacts with various proteins such as CD18. The integrin-mediated signaling pathway sees CD11d playing a role linked to immune cell positioning and movement. It contributes to pathways associated with inflammation such as the activation of leukocytes. The signaling through the CD11d/CD18 complex affects downstream signaling events that modulate cell survival apoptosis and cytokine production.

CD11d plays a role in inflammatory diseases like atherosclerosis and chronic obstructive pulmonary disease (COPD). In atherosclerosis CD11d is linked with macrophage recruitment to the sites of developing arterial plaques. It often interacts with other integrins like CD11b influencing the extent of inflammation and plaque stability. In COPD CD11d contributes to the recruitment and retention of inflammatory cells in the lungs promoting tissue damage and disease progression. Interfering with CD11d expression or its binding capabilities presents potential therapeutic pathways for managing these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

See full target information ITGAD

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Animal bioscience 38:303-315 PubMed39210798

2024

shRNA-interfered of Nrf2 reveals a critical role for Keap1-Nrf2 signaling pathway during effects of zearalenone induced oxidative stress in IPEC-J2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qun Cheng,Shu Zhen Jiang,Li Bo Huang,Wei Ren Yang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD11d antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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