JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB231534

Anti-CD11d antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal CD11d antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Itgad aa 850-1150.

View Alternative Names

CD11d, Integrin alpha-D, Itgad

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11d antibody (AB231534)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11d antibody (AB231534)

Formalin-fixed, paraffin-embedded mouse kidney tissue stained for CD11d using ab231534 at 20 μg/ml in immunohistochemical analysis.

Western blot - Anti-CD11d antibody (AB231534)
  • WB

Supplier Data

Western blot - Anti-CD11d antibody (AB231534)

All lanes:

Western blot - Anti-CD11d antibody (ab231534) at 2 µg/mL

All lanes:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate.

Predicted band size: 129 kDa

false

Western blot - Anti-CD11d antibody (AB231534)
  • WB

Supplier Data

Western blot - Anti-CD11d antibody (AB231534)

All lanes:

Western blot - Anti-CD11d antibody (ab231534) at 2 µg/mL

All lanes:

Recombinant mouse CD11d protein.

Predicted band size: 129 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Mouse Itgad aa 850-1150. The exact immunogen used to generate this antibody is proprietary information.

Q3V0T4

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11d also known as integrin alpha D is a protein that plays a vital role in the adhesion and migration of leukocytes. CD11d forms a heterodimer with CD18 creating the integrin alpha D beta 2 complex. This complex weighs approximately 200 kDa and is expressed mainly on monocytes macrophages and dendritic cells. CD11d is involved in the immune response particularly in the adhesion between cells and the extracellular matrix which facilitates leukocyte trafficking and tissue infiltration.
Biological function summary

CD11d is part of the integrin family a group of proteins that mediate cell surface interactions. It supports the immune surveillance role by allowing immune cells to adhere to and migrate across the vascular endothelium. CD11d is part of the αDβ2 complex which binds to several ligands including ICAM-3 and VCAM-1. This binding is essential for leukocyte migration and establishing immune cell positions during inflammation and immune responses. The protein is expressed more in conditions requiring heightened immune activities or repair.

Pathways

CD11d functions in the leukocyte adhesion cascade and interacts with various proteins such as CD18. The integrin-mediated signaling pathway sees CD11d playing a role linked to immune cell positioning and movement. It contributes to pathways associated with inflammation such as the activation of leukocytes. The signaling through the CD11d/CD18 complex affects downstream signaling events that modulate cell survival apoptosis and cytokine production.

CD11d plays a role in inflammatory diseases like atherosclerosis and chronic obstructive pulmonary disease (COPD). In atherosclerosis CD11d is linked with macrophage recruitment to the sites of developing arterial plaques. It often interacts with other integrins like CD11b influencing the extent of inflammation and plaque stability. In COPD CD11d contributes to the recruitment and retention of inflammatory cells in the lungs promoting tissue damage and disease progression. Interfering with CD11d expression or its binding capabilities presents potential therapeutic pathways for managing these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).
See full target information Itgad
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Drug development research 82:115-122 PubMed32820830

2020

The involvement of protein TNFSF18 in promoting p-STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Gao,Sai Wang,Shilei Liu

Journal of animal science 98: PubMed32171017

2020

Mitochondrial oxygen consumption in early postmortem permeabilized skeletal muscle fibers is influenced by cattle breed.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia M Ramos,Chengcheng Li,Mauricio A Elzo,Stephanie E Wohlgemuth,Tracy L Scheffler
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB34096

Anti-CD11d antibody [CA11.8H2]

  • 0
  • 0
Primary Antibodies

AB196349

Anti-CD11d antibody

  • 1
  • 1
Primary Antibodies

AB231622

Anti-CD11d antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11d antibody (AB231622)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB242740

Anti-IL-10 antibody [EPR17277-226] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-IL-10 antibody [EPR17277-226] - BSA and Azide free (Detector) (AB242740)

  • 0
  • 0
Primary Antibodies

AB183218

Anti-TNF alpha antibody [EPR19147]

KO Validated|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-TNF alpha antibody [EPR19147] (AB183218)

  • 5
  • 1
Primary Antibodies

AB290735

Anti-IL-6 antibody [EPR23819-103]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-6 antibody [EPR23819-103] (AB290735)

  • 5
  • 3
Primary Antibodies

AB283818

Anti-IL-1 beta antibody [RM1009]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry - Anti-IL-1 beta antibody [RM1009] (AB283818)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com