Rabbit Polyclonal CD130 (gp130) antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Mouse Il6st aa 650-750 conjugated to Keyhole Limpet Haemocyanin.
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Publications
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- International journal of molecular sciences 23:2022Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJinrui Dong,Wei-Wen Lim,Shamini G Shekeran,Jessie Tan,Sze Yun Lim,Joyce Wei Ting Goh,Benjamin L George,Sebastian Schafer,Stuart A Cook,Anissa A WidjajaPubMed 35806094
- Cells 11:2022Combination Therapy of Placenta-Derived Mesenchymal Stem Cells with WKYMVm Promotes Hepatic Function in a Rat Model with Hepatic Disease via Vascular Remodeling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJi Hye Jun,Sohae Park,Jae Yeon Kim,Ja-Yun Lim,Gyu Tae Park,Jae Ho Kim,Gi Jin KimPubMed 35053347
- Experimental and therapeutic medicine 22:9992021Metabolites of intestinal microflora upregulate microRNA-200c-3p expression level to suppress airway epithelial inflammation via the IL6ST/JNK/STAT3 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLinliang Hong,Huanhuan Huang,Bin WuPubMed 34345281
- Frontiers in oncology 11:6421342021Bromodomain Inhibition Attenuates the Progression and Sensitizes the Chemosensitivity of Osteosarcoma by Repressing GP130/STAT3 Signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYafei Jiang,Gangyang Wang,Haoran Mu,Xiaojun Ma,Zhuoying Wang,Yu Lv,Tao Zhang,Jing Xu,Jinzeng Wang,Yunqi Li,Jing Han,Mengkai Yang,Zongyi Wang,Ke Zeng,Xinmeng Jin,Song Xue,Mingzhu Yin,Wei Sun,Yingqi Hua,Zhengdong CaiPubMed 34168981
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:20030472021PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCongcong Cai,Shuchen Gu,Yi Yu,Yezhang Zhu,HanChenxi Zhang,Bo Yuan,Li Shen,Bing Yang,Xin-Hua FengPubMed 34026434
- Molecular immunology 128:287-2972020Identification of key genes involved in JAK/STAT pathway in colorectal cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuanyi Yue,Qiang Zhang,Si Wu,Shuang Wang,Changwan Cui,Miao Yu,Zhengrong SunPubMed 33248399
- Aging 12:20184-201972020Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuan Wang et. al.PubMed 33099539
- Experimental and therapeutic medicine 20:3695-37022020Impact of chitosan membrane culture on the expression of pro- and anti-inflammatory cytokines in mesenchymal stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeng Yi et. al.PubMed 32855721
- Cell metabolism 31:327-338.e62020Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEdwin A Rosado-Olivieri et. al.PubMed 31928884
- Biochemical and biophysical research communications 519:572-5782019Gp130 degradation induced by epirubicin contributes to chemotherapy efficacy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFangming Liu,Haizhen Jin,Jinhong Shen,Dan Wu,Ye Tian,Chao HuangPubMed 31537377
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Mouse Il6st aa 650-750 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q00560
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Mouse | Tested |
| Rat | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100 - 1/500 | Notes Use at 1/50 - 1/200 with fluorescent detection methods. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Rat | Dilution info 1/100 - 1/500 | Notes Use at 1/50 - 1/200 with fluorescent detection methods. |
Associated Products
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9 products for Alternative Product
Target data
Function
Signal-transducing molecule (PubMed:1602143). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:10661409, PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (PubMed:9202125). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (PubMed:25731159). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:25057188, PubMed:26255596, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:26255596, PubMed:9348227).
Alternative names
CD130, Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130, Oncostatin-M receptor subunit alpha, gp130, Il6st
Recommended products
Rabbit Polyclonal CD130 (gp130) antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Mouse Il6st aa 650-750 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Mouse Il6st aa 650-750 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q00560
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD130 also known as gp130 or the IL-6 signal transducer (IL6ST) is a protein weighing around 130 kDa. This receptor is encoded by the IL6ST gene and widely expressed on the surface of cells across multiple tissues. CD130 functions mechanically as a signal transducing receptor facilitating the assembly of receptor complexes necessary for the initiation of signal transduction. It plays a major role in cytokine receptor signaling particularly interacting with interleukin-6 (IL-6) family cytokines.
- Biological function summary
CD130 functions as part of the high-affinity receptor complex for certain cytokines. It partners with other receptors such as CD126 to form a complex that initiates signaling pathways after ligand binding contributing to a range of immune responses. Its role is thorough across many cellular processes including differentiation proliferation and apoptosis. In addition to immune signaling CD130 is involved in several growth factor signaling pathways.
- Pathways
CD130 serves a significant role in signal transduction particularly in the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. It works in concert with related proteins like JAK1 and STAT3 to transmit signals from extracellular cytokines to the nucleus influencing gene expression. Additionally CD130 can also be found active in the MAPK/ERK pathway which is important for cellular response to growth signals.
- Associated diseases and disorders
CD130 plays a connection especially to inflammatory conditions and certain cancers. Aberrant signaling involving CD130 has been linked to disorders like rheumatoid arthritis where it contributes to the inflammation process. Additionally it relates to multiple myeloma a cancer where abnormal CD130 interactions with proteins like IL-6 may enhance cell survival and proliferation presenting potential targets for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD130 (gp130) antibody (ab202850)
Immunohistochemical analysis of mouse adrenal tissue labelled for IL-6R Beta/ CD130/ gp130 using ab202850 at 1/200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD130 (gp130) antibody (ab202850)
Immunohistochemical analysis of rat adrenal tissue labelled for IL-6R Beta/ CD130/ gp130 using ab202850 at 1/200 dilution.
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