Rabbit Polyclonal CD134 / OX40L receptor antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TNFRSF4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.
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Publications
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- Oncoimmunology 10:19476652021An immune-based risk-stratification system for predicting prognosis in pulmonary sarcomatoid carcinoma (PSC).Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaoyue Guo,Binglei Li,Li Diao,Hao Wang,Peixin Chen,Minlin Jiang,Lishu Zhao,Yayi He,Caicun ZhouPubMed 34290908
- Neuropathology : official journal of the Japanese Society of Neuropathology :2018Unique cell tropism of HHV-6B in an infantile autopsy case of primary HHV-6B encephalitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHiroaki Miyahara,Kouki Miyakawa,Haruto Nishida,Shinji Yano,Tomoko Sonoda,So-Ichi Suenobu,Tatsuro Izumi,Tsutomu Daa,Kenji IharaPubMed 29582466
- Cancer prevention research (Philadelphia, Pa.) 10:684-6932017PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJin Wang,Tongxin Xie,Bingbing Wang,William N William,John V Heymach,Adel K El-Naggar,Jeffrey N Myers,Carlos CaulinPubMed 29018057
- International journal of molecular medicine 39:144-1522016Immunomodulatory effects of OX40Ig gene-modified adipose tissue-derived mesenchymal stem cells on rat kidney transplantation.Applications:WBReactive species:RatTao Liu,Yue Zhang,Zhongyang Shen,Xunfeng Zou,Xiaobo Chen,Li Chen,Yuliang WangPubMed 27878248
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TNFRSF4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P43489
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Expected | Predicted |
| Mouse | Expected | Tested |
| Rat | Expected | Predicted |
WB
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info Use at an assay dependent concentration. | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes 1/50-1/200 when using fluorescent detection methods. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Human | Dilution info - | Notes - |
Associated Products
Select an associated product type
8 products for Alternative Product
Target data
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Alternative names
CD134, TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor
Recommended products
Rabbit Polyclonal CD134 / OX40L receptor antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TNFRSF4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TNFRSF4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P43489
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.
- Biological function summary
CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.
- Pathways
CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.
- Associated diseases and disorders
CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
This image is courtesy of an anonymous customer review.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody (ab203220)
Formaldehyde-fixed, paraffin-embedded mouse spleen tissue stained for CD134 / OX40L receptor using ab203220 at 1/200 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody (ab203220)
Formaldehyde-fixed, paraffin-embedded mouse spleen tissue stained for CD134 / OX40L receptor using ab203220 at 1/200 dilution in immunohistochemical analysis.
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