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Rat Monoclonal CD134 / OX40L receptor antibody. Carrier free. Suitable for Flow Cyt, CellAct, IHC-Fr and reacts with Mouse samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Tnfrsf4.

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Key facts

Isotype

IgG1

Host species

Rat

Storage buffer

Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Mouse Tnfrsf4. Database link P47741

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow CytCellActInhibIHC-Fr
Mouse
Expected
Expected
Not recommended
Expected

Expected
Expected

Species

Mouse

Dilution info

-

Notes

ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Expected
Expected

Species

Mouse

Dilution info

-

Notes

For the stimulation of T cell proliferation.

Not recommended
Not recommended

Species

Mouse

Dilution info

-

Notes

Does not block the binding of CD134/OX40 to its ligand.

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Associated Products

Select an associated product type

6 products for Alternative Product

Target data

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).

Alternative names

Recommended products

Rat Monoclonal CD134 / OX40L receptor antibody. Carrier free. Suitable for Flow Cyt, CellAct, IHC-Fr and reacts with Mouse samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Tnfrsf4.

Key facts

Isotype

IgG1

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Recombinant Full Length Protein corresponding to Mouse Tnfrsf4. Database link P47741
Carrier free

Yes

Clone number

AP-MAB0833

Purification technique

Affinity purification Protein A

Concentration
Loading...
Purification notes

The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 µm filtered solution. Endotoxin Level: Extremely low level of LPS (< 0.002EU/µg IgG). The antibody is produced by in vitro culture.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

This antibody was produced from a hybridoma (mouse myeloma) fused with
spleen cells from an immunized rat.

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.

Biological function summary

CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.

Pathways

CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.

Associated diseases and disorders

CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.

Product promise

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