AB234169

Anti-CD137 antibody [4B4-1] - Low endotoxin, Azide free

Name: Anti-CD137 antibody [4B4-1] - Low endotoxin, Azide free (ab234169) | Abcam
Brand: Abcam Limited
SKU: AB234169
Price: 905 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal CD137 antibody. Carrier free. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TNFRSF9.

View Alternative Names

CD137, ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA

2 Images

Flow Cytometry - Anti-CD137 antibody [4B4-1] - Low endotoxin, Azide free (AB234169)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD137 antibody [4B4-1] - Low endotoxin, Azide free (AB234169)

Flow cytometry surface staining of human PHA stimulated peripheral blood mononuclear cell suspension labeling CD137 with ab234169 (4 ug/ml) GAM APC.

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD137 antibody [4B4-1] - Low endotoxin, Azide free (AB234169)

Surface staining of CD137 in PHA activated PBMC using ab234169. Gated on singlets.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4B4-1

Isotype

IgG1

Carrier free

Yes

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human TNFRSF9. The exact immunogen used to generate this antibody is proprietary information.

Q07011

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Purity is >95% by SDS-PAGE. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD137 also known as 4-1BB or TNFRSF9 is a protein that functions as a costimulatory receptor in the immune system. It belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 has a mass of approximately 30 kDa. Expression of CD137 occurs mainly on activated T lymphocytes including both CD8+ and CD4+ T cells as well as natural killer (NK) cells dendritic cells and monocytes. The CD137 ligand (CD137L) is the counterpart that engages this receptor transmitting signals important for immune response regulation.

Biological function summary

CD137 plays an important role in T cell activation and survival. It is a member of a receptor-ligand system that enhances immune cell functions. CD137 is part of a receptor complex that when bound by its ligand CD137L promotes cell proliferation and cytokine production. It also supports the development of memory T cells contributing to the body's ability to mount long-term immune responses.

Pathways

CD137 takes part in the NF-kB signaling and MAPK pathways. These pathways are vital for regulating immune responses and inflammation. CD137 signaling through these pathways involves interaction with proteins such as TRAF1 and TRAF2 which help mediate downstream effects critical for cell survival and proliferation. These interactions enhance the body's defense against pathogens and tumors.

CD137 is associated with cancer immunotherapy and autoimmune diseases. In cancer CD137 enhances the anti-tumor activity of immune cells making it a target for immunotherapy strategies. For autoimmune diseases abnormal CD137 expression can lead to excessive immune responses contributing to disease pathogenesis. The protein is also connected to TNF-alpha through its involvement in inflammation suggesting potential intervention points for modulating immune response in related diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).

See full target information TNFRSF9

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature nanotechnology 19:1224-1233 PubMed38802667

2024

Virus-like structures for combination antigen protein mRNA vaccination.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Zhang,Yanmei Li,Fengyuan Zeng,Changyong Mu,Change Liu,Lichun Wang,Xiaowu Peng,Liping He,Yanrui Su,Hongbing Li,An Wang,Lin Feng,Dongxiu Gao,Zhixiao Zhang,Gang Xu,Yixuan Wang,Rong Yue,Junbo Si,Lichun Zheng,Xiong Zhang,Fuyun He,Hongkun Yi,Zhongshu Tang,Gaocan Li,Kaili Ma,Qihan Li

View all publications

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