AB197942

Anti-CD137 antibody

Name: Anti-CD137 antibody (ab197942) | Abcam
Brand: Abcam Limited
SKU: AB197942
Price: 525 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(6 Publications)

Rabbit Polyclonal CD137 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Fusion protein corresponding to TNFRSF9, fused to TNFRSF9.

View Alternative Names

CD137, ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (AB197942)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (AB197942)

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling CD137 with ab197942 at 1/50 diltuion.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (AB197942)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling CD137 with ab197942 at 1/50 diltuion.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Fusion protein corresponding to TNFRSF9, fused to TNFRSF9. The exact immunogen used to generate this antibody is proprietary information.

Q07011

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD137 also known as 4-1BB or TNFRSF9 is a protein that functions as a costimulatory receptor in the immune system. It belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 has a mass of approximately 30 kDa. Expression of CD137 occurs mainly on activated T lymphocytes including both CD8+ and CD4+ T cells as well as natural killer (NK) cells dendritic cells and monocytes. The CD137 ligand (CD137L) is the counterpart that engages this receptor transmitting signals important for immune response regulation.

Biological function summary

CD137 plays an important role in T cell activation and survival. It is a member of a receptor-ligand system that enhances immune cell functions. CD137 is part of a receptor complex that when bound by its ligand CD137L promotes cell proliferation and cytokine production. It also supports the development of memory T cells contributing to the body's ability to mount long-term immune responses.

Pathways

CD137 takes part in the NF-kB signaling and MAPK pathways. These pathways are vital for regulating immune responses and inflammation. CD137 signaling through these pathways involves interaction with proteins such as TRAF1 and TRAF2 which help mediate downstream effects critical for cell survival and proliferation. These interactions enhance the body's defense against pathogens and tumors.

CD137 is associated with cancer immunotherapy and autoimmune diseases. In cancer CD137 enhances the anti-tumor activity of immune cells making it a target for immunotherapy strategies. For autoimmune diseases abnormal CD137 expression can lead to excessive immune responses contributing to disease pathogenesis. The protein is also connected to TNF-alpha through its involvement in inflammation suggesting potential intervention points for modulating immune response in related diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).

See full target information TNFRSF9

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

JACC. Basic to translational science 10:101323 PubMed40737954

2025

CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Alwin de Jong,Thijs J Sluiter,Hendrika A B Peters,Alec Lamens,J Wouter Jukema,Ramon Arens,Paul H A Quax,Margreet R de Vries

Frontiers in oncology 12:969569 PubMed36237314

2022

Clinical implications of the tumor microenvironment using multiplexed immunohistochemistry in patients with advanced or metastatic renal cell carcinoma treated with nivolumab plus ipilimumab.

Applications

Unspecified application

Species

Unspecified reactive species

Jwa Hoon Kim,Gi Hwan Kim,Yeon-Mi Ryu,Sang-Yeob Kim,Hyung-Don Kim,Shin Kyo Yoon,Yong Mee Cho,Jae Lyun Lee

Clinical cancer research : an official journal of the American Association for Cancer Research 28:1027-1037 PubMed34980602

2022

Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ilaria Grazia Zizzari,Alessandra Di Filippo,Andrea Botticelli,Lidia Strigari,Angelina Pernazza,Emma Rullo,Maria Gemma Pignataro,Alessio Ugolini,Fabio Scirocchi,Francesca Romana Di Pietro,Ernesto Rossi,Alain Gelibter,Giovanni Schinzari,Giulia D'Amati,Aurelia Rughetti,Paolo Marchetti,Marianna Nuti,Chiara Napoletano

International journal of clinical and experimental pathology 14:1038-1047 PubMed34760040

2021

Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4), and CD137 in cervical carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ari Kassardjian,Neda A Moatamed

PloS one 13:e0191634 PubMed29360859

2018

A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Zhou,Michael T Bethune,Natalia Malkova,Alexander M Sutherland,Begonya Comin-Anduix,Yapeng Su,David Baltimore,Antoni Ribas,James R Heath

Journal of immunology (Baltimore, Md. : 1950) 198:3999-4011 PubMed28404636

2017

Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Kirstie L S Cleary,H T Claude Chan,Sonja James,Martin J Glennie,Mark S Cragg

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD137 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (AB197942)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (AB197942)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

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