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AB188610

Anti-CD15 antibody [HI98]

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(3 Publications)

Mouse Monoclonal CD15 antibody. Suitable for IHC-P, Flow Cyt and reacts with Human samples. Cited in 3 publications.
2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD15 antibody [HI98] (AB188610)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD15 antibody [HI98] (AB188610)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human uterus tissue labeling CD15 with ab188610 at 1/50 dilution.

Flow Cytometry - Anti-CD15 antibody [HI98] (AB188610)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD15 antibody [HI98] (AB188610)

Flow cytometric analysis of Human peripheral blood granulocytes (right histogram) labeling CD15 with ab188610. FITC-conjugated anti-mouse secondary antibodies were used for the analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HI98

Isotype

IgM

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p>", "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/unavailable/mouse-igm-kappa-monoclonal-mm-30-isotype-control-low-endotoxin-azide-free-ab18400'>ab18400</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD15 also known as Lewis x or 3-fucosyl-N-acetyllactosamine is a carbohydrate antigen with a molecular mass typically not individually defined due to its nature as a glycan. CD15 is expressed on the surface of many human cells including neutrophils and various epithelial cells. It is commonly associated with granulocytes and is used as a cell surface marker. The presence of CD15 can be identified using CD15 antibodies through techniques such as CD15 flow cytometry and CD15 APC labeling.
Biological function summary

CD15 is important in cell-cell interaction mechanisms. It plays a role in mediating adhesion processes particularly in immune responses where it aids neutrophils in adhering to vascular endothelium and transmigrating to sites of infection or inflammation. As a glycoconjugate CD15 forms part of a larger glycoprotein complex on the cell surface interacting with other proteins to facilitate cellular responses and movement.

Pathways

CD15's function as an adhesion molecule ties into key cellular processes such as the selectin pathway. In this pathway it interacts with proteins like E-selectin and L-selectin contributing to leukocyte rolling and extravasation during the immune response. Additionally CD15 is implicated in the signaling pathways that mediate inflammatory responses where its role in neutrophil dynamics is important.

CD15 has notable implications in Hodgkin's lymphoma and certain myeloid leukemias. It is frequently used as a diagnostic marker in these conditions where its overexpression or abnormal expression patterns may signify disease presence or progression. CD15's interaction with other proteins such as CD30 in Hodgkin's lymphoma highlights its utility in understanding the pathological mechanisms and potential therapeutic targets of these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CD15
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:750171 PubMed34671604

2021

miR-371b-5p-Engineered Exosomes Enhances Tumor Inhibitory Effect.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Xue,Yang Yang,Linlin Yang,Xiaodi Yan,Zihao Shen,Jiajia Liu,Jianhua Xue,Wei Zhao,Xianchen Liu

Neurology(R) neuroimmunology & neuroinflammation 8: PubMed34493606

2021

Targeted RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Temporal Arteries From Giant Cell Arteritis Cases Reveals Viral Signatures.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew N Bubak,Teresa Mescher,Michael Mariani,Seth E Frietze,James E Hassell,Christy S Niemeyer,Christina N Como,Anna M Burnet,Prem S Subramanian,Randall J Cohrs,Ravi Mahalingam,Maria A Nagel

Asian spine journal 13:368-376 PubMed30685956

2019

Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuki Sugimoto,Takayuki Nakamura,Takuya Tokunaga,Yusuke Uehara,Tatsuya Okada,Takuya Taniwaki,Toru Fujimoto,Yuichi Oike,Eiichi Nakamura
View all publications
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Product promise

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