AB197979

Anti-CD161 antibody

4

(3 Reviews)

|

(15 Publications)

Rabbit Polyclonal KLRB1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KLRB1.

View Alternative Names

CD161, CLEC5B, NKRP1A, KLRB1, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, Natural killer cell surface protein P1A, NKR-P1A

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD161 antibody (AB197979)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD161 antibody (AB197979)

Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue staining CD161 with ab197979

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

Immunogen

Recombinant Fragment Protein within Human KLRB1. The exact immunogen used to generate this antibody is proprietary information.

style

left-column

Alternative Products

Primary Antibodies

AB233785

Anti-CD161 antibody [4C6A11]

Flow Cytometry - Anti-CD161 antibody [4C6A11] (AB233785)

0
0

Primary Antibodies

AB241100

PE/Cy7® Anti-CD161 antibody [PK136]

Flow Cytometry - PE/Cy7® Anti-CD161 antibody [PK136] (AB241100)

0
0

Primary Antibodies

AB210285

FITC Anti-CD161 antibody [HP-3G10]

Flow Cytometry - FITC Anti-CD161 antibody [HP-3G10] (AB210285)

0
0

Primary Antibodies

AB23624

Anti-CD161 antibody [B199.2]

0
1

Primary Antibodies

AB234107

Anti-CD161 antibody [EPR21236]

20ul selling size|BOND RX™ Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD161 antibody [EPR21236] (AB234107)

4
2

Primary Antibodies

AB231937

Anti-CD161 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD161 antibody (AB231937)

0
0

Primary Antibodies

AB242072

violetFluor™ 450 Anti-CD161 antibody [HP-3G10]

Flow Cytometry - violetFluor™ 450 Anti-CD161 antibody [HP-3G10] (AB242072)

0
0

Complementary Products

Primary Antibodies

AB16669

Anti-CD3 epsilon antibody [SP7]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Multiplex immunohistochemistry - Anti-CD3 epsilon antibody [SP7] (AB16669)

4
80

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

5
20

Primary Antibodies

AB217344

Anti-CD8 alpha antibody [EPR21769]

20ul selling size|RabMAb|Recombinant

Flow Cytometry - Anti-CD8 alpha antibody [EPR21769] (AB217344)

5
6

Primary Antibodies

AB52632

Anti-CD11c antibody [EP1347Y] - C-terminal

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EP1347Y] - C-terminal (AB52632)

5
18

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD161 also known as NKRP1A or KLRB1 is a type II transmembrane protein expressed primarily on natural killer (NK) cells and subsets of T cells. Weighing approximately 30-40 kDa CD161 functions as a C-type lectin receptor involved in the immune response. Its expression can be detected in various tissues including the liver and spleen. Researchers utilize tools such as mouse CD161 PE as well as CD161 APC antibodies for study of its cell surface expression and role in immune modulation.

Biological function summary

CD161 plays a role in immune system regulation by mediating NK cell and T cell activity. It does not operate as part of a complex but interacts with other cellular receptors to modulate immune responses. For example it serves as an inhibitory receptor often through engagement with its ligand LLT1 to temper immune responses and prevent overactivation. This balance is key to maintaining immune homeostasis and facilitates pathogen clearance while avoiding excessive tissue damage.

Pathways

CD161 is involved in the immune checkpoint pathways and is linked to inflammatory response signaling. These pathways play an important role in the immune system's ability to discern self from non-self determining the intensity and character of the body's defense mechanisms. Other proteins such as CTLA-4 and PD-1 also function within these pathways contributing to the regulation of immune cell activity and preventing autoimmunity.

CD161 is associated with inflammatory diseases and cancer. Its involvement in immune checkpoints implicates it in conditions such as autoimmune diseases where it may fail to properly regulate immune activity including multiple sclerosis. In cancer CD161 expression on T cells has been examined in the context of its inhibitory role potentially modulating the immune system's ability to target tumor cells effectively. In these scenarios its interaction with LLT1 and other immune checkpoint proteins influences the disease course and therapeutic outcomes.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

See full target information KLRB1

style

left-column

Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Haematologica : PubMed40820727

2025

Single-cell RNA sequencing reveals heterogeneity of mucosa-associated invariant T cells in donor grafts and its diagnostic relevance in gastrointestinal graft--host disease.

Applications

Unspecified application

Species

Unspecified reactive species

Mengge Gao,Kainan Zhang,Siqi Li,Huidong Guo,Yuqian Sun,Jun Kong,Tingting Han,Yingjun Chang,Xiaojun Huang,Xiaosu Zhao

Gut microbes 17:2470372 PubMed39988618

2025

Upregulation of . in gut microbiota as a novel mechanism for environmental eustress-induced anti-pancreatic cancer effects.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyi Liang,Min Du,Xin Li,Jian Gao,Qian Li,Huimin Li,Jin Li,Xiang Gao,Hui Cong,Yimeng Huang,Xinran Li,Liwei Wang,Jiujie Cui,Yu Gan,Hong Tu

Cancer immunology research 11:306-319 PubMed36633583

2023

CD161 Characterizes an Inflamed Subset of Cytotoxic T Lymphocytes Associated with Prolonged Survival in Human Papillomavirus-Driven Oropharyngeal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Wei,Tingting Xu,Chong Li,Xin Zhou,Wei Qian,Chunying Shen,Qifeng Wang,Xing Xing,Xiaomin Ou,Xiayun He,Hongmei Yin,Chaosu Hu,Yu Wang,Qinghai Ji,Fengtao Su,Xueguan Lu

Frontiers in immunology 13:1040289 PubMed36660546

2022

A pan-cancer and single-cell sequencing analysis of CD161, a promising onco-immunological biomarker in tumor microenvironment and immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

He Li,Ke Zhou,Kaiyue Wang,Hui Cao,Wantao Wu,Zeyu Wang,Ziyu Dai,Shi Chen,Yun Peng,Gelei Xiao,Peng Luo,Jian Zhang,Zaoqu Liu,Quan Cheng,Hao Zhang

International journal of molecular sciences 23: PubMed35886985

2022

Uterine Deletion of Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Masanori Ono,Natsumi Toyoda,Kyosuke Kagami,Takashi Hosono,Takeo Matsumoto,Shin-Ichi Horike,Rena Yamazaki,Mitsuhiro Nakamura,Yasunari Mizumoto,Tomoko Fujiwara,Hitoshi Ando,Hiroshi Fujiwara,Takiko Daikoku

Investigative ophthalmology & visual science 63:18 PubMed35579904

2022

Host Immune Response and Associated Clinical Features in a Primary Cytomegalovirus Eye Infection Model Using Anterior Chamber Inoculation.

Applications

Unspecified application

Species

Unspecified reactive species

Chien-Chia Su,Chia-Mao Gao,Fu-Ti Peng,Tzuu-Shuh Jou,I-Jong Wang

OncoTargets and therapy 14:5263-5273 PubMed34815674

2021

The Study of Mucosal-Associated Invariant T Cells in Colon Cancer and Roles in Immune Activities.

Applications

Unspecified application

Species

Unspecified reactive species

Juanfen Mo,Li Zheng,Zhenzhen Gao,Jiayuan Wu,Yi Bao

Frontiers in immunology 12:720354 PubMed34539656

2021

The Potential Roles of Mucosa-Associated Invariant T Cells in the Pathogenesis of Gut Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Ge Gao,Yan Hong,Xiang-Yu Zhao,Xin-An Pan,Yu-Qian Sun,Jun Kong,Zhi-Dong Wang,Feng-Rong Wang,Jing-Zhi Wang,Chen-Hua Yan,Yu Wang,Xiao-Jun Huang,Xiao-Su Zhao

Cancer discovery 11:3142-3157 PubMed34193438

2021

Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Yuting Tang,Qian Xu,Liang Hu,Xiaomei Yan,Xiaomin Feng,Asumi Yokota,Weinan Wang,Di Zhan,Durga Krishnamurthy,David E Ochayon,Lijun Wen,Li Huo,Huimin Zeng,Yingwan Luo,L Frank Huang,Mark Wunderlich,Jiwang Zhang,Eric Vivier,Jianfeng Zhou,Stephen N Waggoner,Gang Huang

Frontiers in immunology 12:578548 PubMed33815355

2021

CXCL12-CXCR4-Mediated Chemotaxis Supports Accumulation of Mucosal-Associated Invariant T Cells Into the Liver of Patients With PBC.

Applications

Unspecified application

Species

Unspecified reactive species

Zhilei Chen,Suying Liu,Chengmei He,Jinlei Sun,Li Wang,Hua Chen,Fengchun Zhang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com