Anti-CD161 antibody [B199.2]
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(1 Review)
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(2 Publications)
Mouse Monoclonal KLRB1 antibody. Suitable for IP, Flow Cyt, IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing KLRB1 protein.
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CD161, CLEC5B, NKRP1A, KLRB1, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, Natural killer cell surface protein P1A, NKR-P1A
Reactivity data
Product details
Properties and storage information
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Purification technique
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
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Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CD161 plays a role in immune system regulation by mediating NK cell and T cell activity. It does not operate as part of a complex but interacts with other cellular receptors to modulate immune responses. For example it serves as an inhibitory receptor often through engagement with its ligand LLT1 to temper immune responses and prevent overactivation. This balance is key to maintaining immune homeostasis and facilitates pathogen clearance while avoiding excessive tissue damage.
Pathways
CD161 is involved in the immune checkpoint pathways and is linked to inflammatory response signaling. These pathways play an important role in the immune system's ability to discern self from non-self determining the intensity and character of the body's defense mechanisms. Other proteins such as CTLA-4 and PD-1 also function within these pathways contributing to the regulation of immune cell activity and preventing autoimmunity.
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Target data
Publications (2)
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Journal of immunology (Baltimore, Md. : 1950) 196:2085-94 PubMed26829983
2016
Applications
IHC
Species
Unspecified reactive species
Science translational medicine 5:174ra26 PubMed23447017
2013
Applications
IHC-P
Species
Human
Product promise
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