Mouse Monoclonal CD164 antibody. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing CD164 protein.
Images
![Flow Cytometry - Anti-CD164 antibody [67D2] (AB240782), expandable thumbnail](https://content.abcam.com/products/images/cd164-antibody-67d2-ab240782--flow-cytometry-img84843.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - Anti-CD164 antibody [67D2] (AB240782)")
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Cell preparation containing CD164 protein. The exact immunogen used to generate this antibody is proprietary information. Database link Q04900
Reactivity data
Select an application| Flow Cyt | |
|---|---|
| Human | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1-4 µg/mL | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
Alternative names
CD164, Sialomucin core protein 24, MUC-24, Endolyn, Multi-glycosylated core protein 24, MGC-24, MGC-24v
Recommended products
Mouse Monoclonal CD164 antibody. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing CD164 protein.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Cell preparation containing CD164 protein. The exact immunogen used to generate this antibody is proprietary information. Database link Q04900
- Clone number
- 67D2
- Purification technique
- Affinity purification Protein A
- Concentration
- Purification notes
Purified from hybridoma culture supernatant.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD164 also known as endolyn is a sialomucin protein with a molecular weight of approximately 80 to 90 kDa. It is a cell surface glycoprotein found on hematopoietic progenitor cells stromal cells epithelial cells and certain cancer cells. The expression of CD164 plays a part in the regulation of adhesion migration and cellular localization which affects cell proliferation and tissue development. It acts as a high-affinity receptor for novel inflammatory cytokines and modulates interactions with other cellular molecules.
- Biological function summary
CD164 influences the adhesive properties within specific cellular environments. It contributes to the formation of complexes with other cellular proteins to modulate cell communication and migration. The interaction of CD164 with integrins and cell surface receptors regulates cellular trafficking. It influences the behavior of cells at high confluency which impacts how these cells aggregate and differentiate in tissue structures.
- Pathways
More than four biochemical interactions influence CD164's role in controlling cellular movement and tissue architecture. It plays a significant role in the chemokine signaling pathway affecting memory B-cell homing. Furthermore CD164 is linked with the transforming growth factor-beta (TGF-beta) pathway through its association with integrins which regulates numerous cellular processes such as growth and development. By modulating these pathways it participates in the body's response to injury and inflammation.
- Associated diseases and disorders
Aberrant CD164 expression or function has been linked to various pathological conditions. For instance changes in CD164 levels are observed in certain leukemia types where its overexpression may contribute to abnormal cell growth and survival. Additionally its interaction with proteins like CXCR4 has implications in the metastasis of breast cancer enhancing the invasiveness of cancer cells. Therefore CD164's involvement in these diseases highlights its potential as a therapeutic target in cancer research.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Flow Cytometry - Anti-CD164 antibody [67D2] (ab240782), expandable thumbnail](https://content.abcam.com/products/images/cd164-antibody-67d2-ab240782--flow-cytometry-img84843.jpg "Flow Cytometry - Anti-CD164 antibody [67D2] (ab240782)")
Flow Cytometry - Anti-CD164 antibody [67D2] (ab240782)
Flow cytometric analysis of human peripheral blood cells labeling CD164 using ab240782, followed by Goat-Anti Mouse (APC).
Gated on human leukocytes. Overlay between specific antibody signal (red) and background signal (blue).
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