AB203025

Anti-CD177 antibody

Name: Anti-CD177 antibody (ab203025) | Abcam
Brand: Abcam Limited
SKU: AB203025
Price: 525 USD
Availability: InStock
Rating: 1 (1 reviews)

(1 Review)

(4 Publications)

Rabbit Polyclonal CD177 molecule antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 4 publications.

View Alternative Names

Cd177

1 Images

Supplier Data

Western blot - Anti-CD177 antibody (AB203025)

All lanes:

Western blot - Anti-CD177 antibody (ab203025) at 1/1000 dilution

Lane 1:

Mouse Spleen lysate

Lane 2:

Mouse RAW264.7 cell lysate

Lane 3:

Rat lymph node lysate

Secondary

All lanes:

Conjugated secondary at 1/20000 dilution

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Mouse

Applications

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/300 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/300 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD177 also known as neutrophil antigen NB1 is a glycoprotein with an approximate mass of 58 kDa. It is primarily expressed on the surface of neutrophils a type of white blood cell involved in immune response. The expression of CD177 can vary among individuals where some people might have a higher or lower presence on their neutrophils. CD177 has been identified to play a role in cell adhesion and signaling functions contributing to various cellular processes within the immune system.

Biological function summary

CD177 functions by mediating interactions between neutrophils and endothelial cells during inflammation. This protein is not known to be part of a multi-protein complex but it plays a significant role in facilitating neutrophil transmigration from blood vessels to sites of tissue damage or infection. This process supports the body's defense mechanisms by enabling neutrophils to quickly respond to external threats and participate in the inflammatory response.

Pathways

The involvement of CD177 in chemotactic activity and cell migration highlights its contribution to both the immune response and inflammation pathways. Its interaction with proteins such as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) enhances neutrophil transmigration across the endothelium. CD177 acts within these pathways to ensure a precise and rapid movement of neutrophils which is essential for an effective immune response.

CD177 levels have associations with conditions like polycythemia vera and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. In polycythemia vera CD177 can affect the proliferation of blood cells due to its role in neutrophil function. In ANCA-associated vasculitis CD177's interaction with proteins such as PR3 (Proteinase 3) on the surface of neutrophils could contribute to the pathophysiology of the disease leading to inappropriate activation of the immune system and subsequent tissue damage.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information CD177 molecule

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in genetics 11:566024 PubMed33193652

2020

Novel Gene Signature Reveals Prognostic Model in Acute Myeloid Leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Qu,Shuying Zhang,Yanzhang Qu,Heng Guo,Suling Wang,Xuemei Wang,Tianjiao Huang,Hong Zhou

The Journal of clinical investigation 129:4091-4109 PubMed31295147

2019

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Jimenez Calvente,Masahiko Tameda,Casey D Johnson,Hana Del Pilar,Yun Chin Lin,Nektaria Adronikou,Xavier De Mollerat Du Jeu,Cristina Llorente,Josh Boyer,Ariel E Feldstein

Experimental and therapeutic medicine 15:2719-2726 PubMed29456674

2018

Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit.

Applications

Unspecified application

Species

Unspecified reactive species

Qiu-Yue Liu,Fen Han,Li-Ping Pan,Hong-Yan Jia,Qi Li,Zong-De Zhang

Molecular medicine reports 14:1083-90 PubMed27279017

2016

Roscovitine ameliorates endotoxin-induced uveitis through neutrophil apoptosis.

Applications

IHC-P

Species

Mouse

Zhao-Xin Jiang,Suo Qiu,Bing-Sheng Lou,Yao Yang,Wen-Cong Wang,Xiao-Feng Lin

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD177 antibody

Western blot - Anti-CD177 antibody (AB203025)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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