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AB201337

Anti-CD1a antibody [C1A/711]

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(8 Publications)

Mouse Monoclonal CD1A antibody. Suitable for IHC-P, IP, Flow Cyt, WB, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CD1A.

View Alternative Names

CD1a, T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1A

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1a antibody [C1A/711] (AB201337)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1a antibody [C1A/711] (AB201337)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling CD1a with ab201337 at 1 μg/ml.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C1A/711

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, IHC-P, IP, WB, ICC/IF, IHC-Fr

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CD1A.

P06126

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p>For 30 min at RT.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>For 30 min at RT.</p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
ab201337 is purified from Bioreactor Concentrate.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD1a also known as T6 antigen or CD1 is a protein with an estimated molecular mass of 37 kDa. It is expressed mainly on the surface of Langerhans cells in the skin and dendritic cells in the thymus. CD1a belongs to the CD1 family which presents lipid antigens to T cells. The protein is an important marker in immunophenotyping of these dendritic cells making it useful in flow cytometry applications.
Biological function summary

CD1a participates in the immune system by presenting lipid and glycolipid antigens to T lymphocytes including natural killer T (NKT) cells. It forms a complex with β2-microglobulin which is essential for its proper function and antigen presentation. CD1a expression helps differentiate between types of dendritic cells with CD1a-positive cells often engaging in specific responses to microbial lipid antigens.

Pathways

CD1a plays a significant role in the antigen presentation pathway particularly in lipid antigen presentation to T cells. This is important for initiating immune responses. It interacts with related proteins such as CD1b and CD1c which also present lipid antigens. CD1a has implications in innate and adaptive immunity and can influence pathways involved in microbial recognition and elimination.

CD1a is associated with certain skin conditions like Langerhans Cell Histiocytosis and psoriasis. It is involved in the pathogenesis of these diseases by affecting immune responses in the skin. In Langerhans Cell Histiocytosis CD1a-positive cells accumulate abnormally. Additionally CD1a is often studied alongside related proteins like CD207 (Langerin) to understand these conditions better.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
See full target information CD1A

Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:30313 PubMed40830367

2025

Three-dimensional analysis of intraepidermal nerve fibres and Langerhans cells in keloids with a focus on pruritus.

Applications

Unspecified application

Species

Unspecified reactive species

Haruka Matsuzoe,Koh-Ei Toyoshima,Miki Takase,Ayako Tsuchiya,Mika Ikeda,Motoko Naitoh,Kazuya Kataoka,Tomoya Kawabata,Miho Ogawa,Naoki Morimoto,Takashi Tsuji

Bioengineering & translational medicine 10:e10738 PubMed40060763

2025

Assessing the impact of airborne particulate pollution on human skin utilizing a novel human skin equivalent containing MUTZ-3-derived Langerhans cells.

Applications

Unspecified application

Species

Unspecified reactive species

Amy Simpson,Teresa DiColandrea,Stefan Przyborski

Parasite immunology 45:e12971 PubMed36695719

2023

Role of antigen-presenting cells in non-ulcerated skin lesions caused by Leishmania (Leishmania) infantum chagasi.

Applications

Unspecified application

Species

Unspecified reactive species

Carmen M Sandoval Pacheco,Gabriela V Araujo Flores,Aurea F Ferreira,Vânia L R da Matta,Claudia M de Castro Gomes,Wilfredo H Sosa-Ochoa,Concepción Zúniga,Fernando T Silveira,Carlos E P Corbett,Márcia D Laurenti

Scientific data 6:323 PubMed31848351

2019

Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Rumana Rashid,Giorgio Gaglia,Yu-An Chen,Jia-Ren Lin,Ziming Du,Zoltan Maliga,Denis Schapiro,Clarence Yapp,Jeremy Muhlich,Artem Sokolov,Peter Sorger,Sandro Santagata

Free radical biology & medicine 139:80-91 PubMed31078730

2019

Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8 T cells activation via JAK-STAT pathway in vitiligo.

Applications

Unspecified application

Species

Unspecified reactive species

Xuguang Chen,Weinan Guo,Yuqian Chang,Jiaxi Chen,Pan Kang,Xiuli Yi,Tingting Cui,Sen Guo,Qian Xiao,Zhe Jian,Kai Li,Tianwen Gao,Shuli Li,Ling Liu,Chunying Li

Photodiagnosis and photodynamic therapy 26:270-276 PubMed30986538

2019

5-Aminolevulinic acid photodynamic therapy with and without Er:YAG laser for actinic keratosis: Changes in immune infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Emese Gellén,Eszter Fidrus,Eszter Janka,Sándor Kollár,György Paragh,Gabriella Emri,Éva Remenyik

International journal of cancer 144:117-124 PubMed30098202

2018

A novel fusion gene PLEKHA6-NTRK3 in langerhans cell histiocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaoyang Cai,Xia Huang,Minzhi Yin,Ci Pan,Lili Song,Zhiyan Zhan,Jing Chen,Yijin Gao,Jingyan Tang,Yanxin Li,Shuhong Shen

The British journal of dermatology 177:809-817 PubMed28132413

2017

Immunotolerant indoleamine-2,3-dioxygenase is increased in condyloma acuminata.

Applications

Unspecified application

Species

Unspecified reactive species

Z Xie,M Zhang,W Xiong,H Y Wan,X C Zhao,T Xie,H Lei,Z C Lin,D S Luo,X L Liang,Y H Chen
View all publications

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