JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB18216

Anti-CD1c antibody [M241]

Be the first to review this product! Submit a review

|

(4 Publications)

Mouse Monoclonal CD1C antibody. Suitable for IHC, IP, RID and reacts with Human samples. Cited in 4 publications.

View Alternative Names

CD1c, T-cell surface glycoprotein CD1c, CD1C

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

M241

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IP, IHC, RID

applications

style
left-column

Alternative Products

Primary Antibodies

AB190305

Anti-CD1c antibody [L161]

KO Validated

Flow Cytometry - Anti-CD1c antibody [L161] (AB190305)

  • 0
  • 0
Primary Antibodies

AB167419

Anti-CD1c antibody [EPR9638]

RabMAb|Recombinant

Western blot - Anti-CD1c antibody [EPR9638] (AB167419)

  • 0
  • 0
Primary Antibodies

AB156708

Anti-CD1c antibody [OTI2F4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

  • 5
  • 4

Complementary Products

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 19
Primary Antibodies

AB223188

Anti-CLEC9A antibody [EPR22324]

RabMAb|Recombinant

Flow Cytometry - Anti-CLEC9A antibody [EPR22324] (AB223188)

  • 0
  • 0
Primary Antibodies

AB955

Anti-CD68 antibody [KP1]

Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [KP1] (AB955)

  • 4
  • 48
Primary Antibodies

AB52632

Anti-CD11c antibody [EP1347Y] - C-terminal

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EP1347Y] - C-terminal (AB52632)

  • 5
  • 18
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "RID" : {"fullname" : "Radial Immunodiffusion", "shortname":"RID"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHC-species-checked": "guaranteed", "IHC-species-dilution-info": "", "IHC-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "RID-species-checked": "guaranteed", "RID-species-dilution-info": "", "RID-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD1c also known as CD1c molecule or R7 is a transmembrane glycoprotein with a molecular weight of approximately 43 kDa. It belongs to the CD1 family of glycoproteins which share structural similarity to major histocompatibility complex (MHC) proteins. CD1c presents lipid and glycolipid antigens to T cells. It is expressed on professional antigen-presenting cells (APCs) like dendritic cells B cells and some monocytes. This expression allows CD1c to function in the immune response by presenting specialized antigens to T cells.
Biological function summary

The function of CD1c involves the presentation of lipid antigens which plays a role in immune recognition. CD1c is a part of a complex that includes β2-microglobulin which stabilizes its structure for antigen presentation. CD1c contributes to the immune surveillance by enabling the recognition of microbial lipid antigens as well as self-lipids by specific T cell subsets. This function supports the body's immune defense by identifying and reacting to potential pathogenic lipids.

Pathways

CD1c is involved in immune response pathways that center around antigen presentation. It interacts with other proteins like CD1a CD1b and CD1d expanding the range of antigens that T cells can recognize. CD1c participates in the lipid antigen presentation pathway influencing both innate and adaptive immunity. The presentation of lipid antigens by CD1c to T cells can trigger signaling pathways that affect both immune activation and resolution.

CD1c is implicated in autoimmune diseases and infections. Its role in antigen presentation makes it a potential factor in autoimmune conditions where immune recognition errors might occur. Additionally CD1c may relate to infectious diseases where mycobacteria or other pathogens present unique lipid antigens. Through its interaction with T cell receptors CD1c can impact how well immune responses are mounted against these challenges making it a notable target for therapeutic development and research.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
See full target information CD1C
style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 45:390-400 PubMed33200225

2020

Dual inhibition of FOXM1 and its compensatory signaling pathway decreased the survival of ovarian cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dae Woo Lee,Weonsun Lee,Miyeon Kwon,Hae Nam Lee

Cellular and molecular gastroenterology and hepatology 5:31-49 PubMed29188232

2017

Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System.

Applications

Unspecified application

Species

Unspecified reactive species

Emilie Duchalais,Christophe Guilluy,Steven Nedellec,Melissa Touvron,Anne Bessard,Yann Touchefeu,Céline Bossard,Hélène Boudin,Guy Louarn,Michel Neunlist,Laurianne Van Landeghem

Human immunology 25:181-93 PubMed2670851

1989

Characterization of B cells in severe combined immunodeficiency disease.

Applications

Unspecified application

Species

Unspecified reactive species

T N Small,C Keever,N Collins,B Dupont,R J O'Reilly,N Flomenberg

European journal of immunology 12:676-81 PubMed6754387

1982

A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin.

Applications

Unspecified application

Species

Unspecified reactive species

R W Knowles,W F Bodmer
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com