AB201984

Anti-CD200 / OX2 antibody [6E8B11]

Name: Anti-CD200 / OX2 antibody [6E8B11] (ab201984) | Abcam
Brand: Abcam Limited
SKU: AB201984
Price: 535 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal CD200 / OX2 antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CD200 aa 50 to C-terminus.

View Alternative Names

CD200, MOX1, MOX2, My033, OX-2 membrane glycoprotein

2 Images

Supplier Data

Western blot - Anti-CD200 / OX2 antibody [6E8B11] (AB201984)

All lanes:

Western blot - Anti-CD200 / OX2 antibody [6E8B11] (ab201984) at 1/500 dilution

Lane 1:

HEK293 cell lysate

Lane 2:

CD200 / OX2 (aa56-257)-hIgGFc transfected HEK293 cell lysate

Predicted band size: 31 kDa

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Supplier Data

Western blot - Anti-CD200 / OX2 antibody [6E8B11] (AB201984)

Expected MWt is 48.4 kDa.

All lanes:

Western blot - Anti-CD200 / OX2 antibody [6E8B11] (ab201984) at 1/500 dilution

All lanes:

Human CD200 / OX2 (aa56-257) recombinant protein

Predicted band size: 31 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

6E8B11

Isotype

IgG2a

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human CD200 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P41217

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified from tissue culture supernatant.

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

See full target information CD200

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 221: PubMed36205720

2022

Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration.

Applications

Unspecified application

Species

Unspecified reactive species

Amaris Guevara-Garcia,Laure Fourel,Ingrid Bourrin-Reynard,Adria Sales,Christiane Oddou,Mylène Pezet,Olivier Rossier,Paul Machillot,Line Chaar,Anne-Pascale Bouin,Gregory Giannone,Olivier Destaing,Catherine Picart,Corinne Albiges-Rizo

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD200 / OX2 antibody [6E8B11]

Western blot - Anti-CD200 / OX2 antibody [6E8B11] (AB201984)

Western blot - Anti-CD200 / OX2 antibody [6E8B11] (AB201984)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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