AB203887

Anti-CD200 / OX2 antibody

Name: Anti-CD200 / OX2 antibody (ab203887) | Abcam
Brand: Abcam Limited
SKU: AB203887
Price: 525 USD
Availability: InStock

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(11 Publications)

Rabbit Polyclonal CD200 / OX2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human CD200 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CD200, MOX1, MOX2, My033, OX-2 membrane glycoprotein

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD200 / OX2 antibody (AB203887)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD200 / OX2 antibody (AB203887)

Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human lung carcinoma tissue labeling CD200 / OX2 with ab203887 at 1/200 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD200 / OX2 antibody (AB203887)

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling CD200 / OX2 with ab203887 at 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CD200 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P41217

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe the recommended dilution is 1/50-1/200.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

See full target information CD200

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology, immunotherapy : CII 73:96 PubMed38619621

2024

CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica Wedig,Shrina Jasani,Debasmita Mukherjee,Hannah Lathrop,Priya Matreja,Timothy Pfau,Liliana D'Alesio,Abigail Guenther,Lexie Fenn,Morgan Kaiser,Molly A Torok,Jake McGue,Gina M Sizemore,Anne M Noonan,Mary E Dillhoff,Bradley W Blaser,Timothy L Frankel,Stacey Culp,Phil A Hart,Zobeida Cruz-Monserrate,Thomas A Mace

Molecular medicine reports 27: PubMed36484353

2022

Significance of placental CD200 expression in patients with preeclampsia: Comparison between early‑ and late‑onset patients.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroaki Tsubokura,Mitsuaki Ishida,Akemi Nishigaki,Takuya Yokoe,Shinnosuke Komiya,Yusuke Butsuhara,Aya Yoshida,Yoji Hisamatsu,Yoshiko Hashimoto,Tomoko Tsuzuki-Nakao,Hiromi Murata,Koji Tsuta,Hidetaka Okada

Journal of cutaneous pathology 49:1044-1050 PubMed36445269

2022

Merkel cell number and distribution, and CD200 expression in patients with lichen planopilaris and discoid lupus erythematosus.

Applications

Unspecified application

Species

Unspecified reactive species

Ece Erbağcı,Ayşen Karaduman,Özay Gököz,Sibel Ersoy Evans

American journal of translational research 13:2365-2378 PubMed34017395

2021

Myocardial infarction cardiomyocytes-derived exosomal miR-328-3p promote apoptosis via Caspase signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jiechun Huang,Fangrui Wang,Xiaotian Sun,Xianglin Chu,Rongrong Jiang,Yiqing Wang,Liewen Pang

Frontiers in cell and developmental biology 9:648578 PubMed33693006

2021

Electroacupuncture Reduces Oocyte Number and Maintains Vascular Barrier Against Ovarian Hyperstimulation Syndrome by Regulating CD200.

Applications

Unspecified application

Species

Unspecified reactive species

Li Chen,Xuan Huang,Li Wang,Cencen Wang,Xu Tang,Minghui Gu,Jun Jing,Rujun Ma,Xie Ge,Bing Yao

Journal of neuroinflammation 17:247 PubMed32829711

2020

The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours.

Applications

Unspecified application

Species

Unspecified reactive species

Katarzyna Chamera,Katarzyna Kotarska,Magdalena Szuster-Głuszczak,Ewa Trojan,Alicja Skórkowska,Bartosz Pomierny,Weronika Krzyżanowska,Natalia Bryniarska,Agnieszka Basta-Kaim

The Journal of dermatology 47:1317-1321 PubMed32794263

2020

Single administration of avelumab induced a complete response in thyroid transcription factor 1-positive combined Merkel cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hisashi Kanemaru,Satoshi Fukushima,Yukari Mizukami,Soichiro Sawamura,Kayo Nakamura,Noritoshi Honda,Katsunari Makino,Ikko Kajihara,Jun Aoi,Takamitsu Makino,Takeshi Kawasaki,Erina Kudou,Masayoshi Jhono,Takaaki Ito,Nobuyuki Arima,Hironobu Ihn

Scientific reports 10:6740 PubMed32317718

2020

Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens.

Applications

Unspecified application

Species

Unspecified reactive species

Yushi Hayashi,Hidenori Suzuki,Wataru Nakajima,Ikuno Uehara,Atsuko Tanimura,Toshiki Himeda,Satoshi Koike,Tatsuya Katsuno,Shin-Ichiro Kitajiri,Naoto Koyanagi,Yasushi Kawaguchi,Koji Onomoto,Hiroki Kato,Mitsutoshi Yoneyama,Takashi Fujita,Nobuyuki Tanaka

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 68:945-955 PubMed31444514

2019

Anti-angiogenic and anti-inflammatory effects of CD200-CD200R1 axis in oxygen-induced retinopathy mice model.

Applications

Unspecified application

Species

Unspecified reactive species

Yaguang Hu,Ting Wei,Shan Gao,Qiaochu Cheng

Frontiers in cellular neuroscience 12:507 PubMed30631265

2018

Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery.

Applications

Unspecified application

Species

Unspecified reactive species

Elvira R Akhmetzyanova,Yana O Mukhamedshina,Margarita N Zhuravleva,Luisa R Galieva,Alexander A Kostennikov,Ekaterina E Garanina,Albert A Rizvanov

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD200 / OX2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD200 / OX2 antibody (AB203887)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD200 / OX2 antibody (AB203887)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Product promise