Rabbit Polyclonal CD204 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Synthetic Peptide within Human MSR1 aa 300-400.
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- EBioMedicine 90:1044802023A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYawei Wang,Binlin Tang,Huijuan Li,Jiancheng Zheng,Can Zhang,Zeyu Yang,Xu Tan,Peng Luo,Le Ma,Yang Wang,Lei Long,Zelin Chen,Zhenliang Xiao,Lijie Ma,Jing Zhou,Yu Wang,Chunmeng ShiPubMed 36863256
- Frontiers in immunology 13:8397962022Activation of RARα Receptor Attenuates Neuroinflammation After SAH Promoting M1-to-M2 Phenotypic Polarization of Microglia and Regulating Mafb/Msr1/PI3K-Akt/NF-κB Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Tian,Binbing Liu,Yuchen Li,Yongzhi Zhang,Jiang Shao,Pei Wu,Chao Xu,Guangduo Chen,Huaizhang ShiPubMed 35237277
- Journal of fish diseases 45:19-332021Implication of mucus-secreting cells, acidophilic granulocytes and monocytes/macrophages in the resolution of skin inflammation caused by subcutaneous injection of λ/κ-carrageenin to gilthead seabream (Sparus aurata) specimens.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJosé Carlos Campos-Sánchez,Enrica Vitarelli,Francisco A Guardiola,Diana Ceballos-Francisco,José María García Beltrán,Antonio Ieni,María Ángeles EstebanPubMed 34549432
- OncoTargets and therapy 13:12829-128432020Tumor-Linked Macrophages Promote HCC Development by Mediating the CCAT1/Let-7b/HMGA2 Signaling Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiang Deng et. al.PubMed 33363387
- Cell death & disease 11:6362020Deubiquitination of CD36 by UCHL1 promotes foam cell formation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaohong Xia et. al.PubMed 32801299
- Frontiers in cell and developmental biology 8:2872020An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMei-Yu Quan et. al.PubMed 32457900
- Journal of neuroinflammation 17:622020Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFan-Qi Kong et. al.PubMed 32066456
- Journal of cellular and molecular medicine 24:3292-33022020Inhibition of USP14 suppresses the formation of foam cell by promoting CD36 degradation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFangcheng Zhang et. al.PubMed 31970862
- Theranostics 10:17-352020Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShu-Jie Zhao et. al.PubMed 31903103
- BioMed research international 2019:92768312019Gastrodin Ameliorates Acute Rejection via IRE1/TRAF2/NF-B in Rats Receiving Liver Allografts.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFangchao Yuan et. al.PubMed 31828147
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 69% PBS, 30% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human MSR1 aa 300-400. The exact immunogen used to generate this antibody is proprietary information. Database link P21757
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.5 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes - |
Associated Products
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3 products for Alternative Product
Target data
Function
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586).
Alternative names
CD204, SCARA1, MSR1, Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1
Recommended products
Rabbit Polyclonal CD204 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Synthetic Peptide within Human MSR1 aa 300-400.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 69% PBS, 30% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human MSR1 aa 300-400. The exact immunogen used to generate this antibody is proprietary information. Database link P21757
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 6 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD204 also known as MSR1 or the macrophage scavenger receptor 1 is a class A scavenger receptor. It has a molecular mass of approximately 80-85 kDa. CD204 is mainly expressed on the surface of macrophages as well as some dendritic cells. This receptor plays a role in mediating the endocytosis of various polyanionic molecules such as modified low-density lipoproteins. CD204 serves as a recognition site for apoptotic cells signaling molecules and some types of bacteria.
- Biological function summary
CD204 influences inflammatory responses and lipid metabolism. It does not function alone but as part of a complex involving several other molecules like pattern recognition receptors. CD204 recognizes and binds to modified lipoproteins and is significant in processes like phagocytosis and clearance of cellular debris. Its activity affects immune response modulation and can influence atherosclerosis development by its interaction with oxidized low-density lipoproteins.
- Pathways
The role of CD204 extends to key cellular and immunological pathways. This receptor is involved in the Toll-like receptor signaling pathway which is important for innate immunity besides participating in the macrophage activation pathways. In these pathways CD204 interacts with other proteins including CD36 and SRA. This interaction helps coordinate inflammatory responses and the resolution of inflammation.
- Associated diseases and disorders
CD204 is associated with atherosclerosis and chronic inflammation. Its connection with these conditions arises from its role in lipid uptake and immune cell regulation within the vascular system. In the context of atherosclerosis CD204's interaction with Apolipoprotein E (ApoE) influences the formation of foam cells which are significant in the disease's progression. Similarly in chronic inflammation CD204 modulates macrophage behavior impacting the inflammatory environment and potentially affecting the disease outcome.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-CD204 antibody (ab123946)
All lanes: Western blot - Anti-CD204 antibody (ab123946) at 0.5 µg/mL
All lanes: Human liver lysate
Predicted band size: 50 kDa
Observed band size: 50 kDa
Immunocytochemistry/ Immunofluorescence - Anti-CD204 antibody (ab123946)
ab123946, at a 1/50 dilution, staining CD204 (green) in Hela cells by Immunofluorescence. Nuclei (blue) are counterstained using Hoechst 33258.
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