AB123946

Anti-CD204 antibody

Name: Anti-CD204 antibody (ab123946) | Abcam
Brand: Abcam Limited
SKU: AB123946
Price: 525 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(21 Publications)

Rabbit Polyclonal CD204 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 21 publications. Immunogen corresponding to Synthetic Peptide within Human MSR1 aa 300-400.

View Alternative Names

CD204, SCARA1, MSR1, Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1

2 Images

Unknown

Western blot - Anti-CD204 antibody (AB123946)

All lanes:

Western blot - Anti-CD204 antibody (ab123946) at 0.5 µg/mL

All lanes:

Human liver lysate

Predicted band size: 50 kDa

Observed band size: 50 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-CD204 antibody (AB123946)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CD204 antibody (AB123946)

ab123946, at a 1/50 dilution, staining CD204 (green) in Hela cells by Immunofluorescence. Nuclei (blue) are counterstained using Hoechst 33258.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human MSR1 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

P21757

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.1% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

Up to 6 months

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD204 also known as MSR1 or the macrophage scavenger receptor 1 is a class A scavenger receptor. It has a molecular mass of approximately 80-85 kDa. CD204 is mainly expressed on the surface of macrophages as well as some dendritic cells. This receptor plays a role in mediating the endocytosis of various polyanionic molecules such as modified low-density lipoproteins. CD204 serves as a recognition site for apoptotic cells signaling molecules and some types of bacteria.

Biological function summary

CD204 influences inflammatory responses and lipid metabolism. It does not function alone but as part of a complex involving several other molecules like pattern recognition receptors. CD204 recognizes and binds to modified lipoproteins and is significant in processes like phagocytosis and clearance of cellular debris. Its activity affects immune response modulation and can influence atherosclerosis development by its interaction with oxidized low-density lipoproteins.

Pathways

The role of CD204 extends to key cellular and immunological pathways. This receptor is involved in the Toll-like receptor signaling pathway which is important for innate immunity besides participating in the macrophage activation pathways. In these pathways CD204 interacts with other proteins including CD36 and SRA. This interaction helps coordinate inflammatory responses and the resolution of inflammation.

CD204 is associated with atherosclerosis and chronic inflammation. Its connection with these conditions arises from its role in lipid uptake and immune cell regulation within the vascular system. In the context of atherosclerosis CD204's interaction with Apolipoprotein E (ApoE) influences the formation of foam cells which are significant in the disease's progression. Similarly in chronic inflammation CD204 modulates macrophage behavior impacting the inflammatory environment and potentially affecting the disease outcome.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed : 2251254). Isoform III does not internalize acetylated LDL (PubMed : 9548586).

See full target information MSR1

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Publications (21)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e22846 PubMed36856983

2023

Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation.

Applications

Unspecified application

Species

Unspecified reactive species

Nisha Schwarz,Sanuja Fernando,Yung-Chih Chen,Thalia Salagaras,Sushma R Rao,Sanuri Liyanage,Anna E Williamson,Deborah Toledo-Flores,Catherine Dimasi,Timothy J Sargeant,Jim Manavis,Eleanor Eddy,Peter Kanellakis,Peter L Thompson,Joanne T M Tan,Marten F Snel,Christina A Bursill,Stephen J Nicholls,Karlheinz Peter,Peter J Psaltis

EBioMedicine 90:104480 PubMed36863256

2023

A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.

Applications

Unspecified application

Species

Unspecified reactive species

Yawei Wang,Binlin Tang,Huijuan Li,Jiancheng Zheng,Can Zhang,Zeyu Yang,Xu Tan,Peng Luo,Le Ma,Yang Wang,Lei Long,Zelin Chen,Zhenliang Xiao,Lijie Ma,Jing Zhou,Yu Wang,Chunmeng Shi

Frontiers in immunology 13:839796 PubMed35237277

2022

Activation of RARα Receptor Attenuates Neuroinflammation After SAH Promoting M1-to-M2 Phenotypic Polarization of Microglia and Regulating Mafb/Msr1/PI3K-Akt/NF-κB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Tian,Binbing Liu,Yuchen Li,Yongzhi Zhang,Jiang Shao,Pei Wu,Chao Xu,Guangduo Chen,Huaizhang Shi

Cancer medicine 11:2020-2035 PubMed35142109

2022

Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Qiankun Ji,Kai Huang,Yuan Jiang,Kunjian Lei,Zewei Tu,Haitao Luo,Xingen Zhu

Journal of fish diseases 45:19-33 PubMed34549432

2021

Implication of mucus-secreting cells, acidophilic granulocytes and monocytes/macrophages in the resolution of skin inflammation caused by subcutaneous injection of λ/κ-carrageenin to gilthead seabream (Sparus aurata) specimens.

Applications

Unspecified application

Species

Unspecified reactive species

José Carlos Campos-Sánchez,Enrica Vitarelli,Francisco A Guardiola,Diana Ceballos-Francisco,José María García Beltrán,Antonio Ieni,María Ángeles Esteban

Frontiers in immunology 12:670646 PubMed33936116

2021

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Fanqi Kong,Kaiqiang Sun,Jian Zhu,Fudong Li,Feng Lin,Xiaofei Sun,Xi Luo,Changzhen Ren,Lantao Lu,ShuJie Zhao,Jingchuan Sun,Yuan Wang,Jiangang Shi

OncoTargets and therapy 13:12829-12843 PubMed33363387

2020

Tumor-Linked Macrophages Promote HCC Development by Mediating the CCAT1/Let-7b/HMGA2 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Deng,Shan Huang,Bin Chen,Yajun Tang,Fei Huang,Dong Li,Di Tang

Cell death & disease 11:636 PubMed32801299

2020

Deubiquitination of CD36 by UCHL1 promotes foam cell formation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohong Xia,Qiong Xu,Mingke Liu,Xuke Chen,Xiaolin Liu,Jinchan He,Tumei Hu,Cuifu Yu,Hongbiao Huang,Shiming Liu,Ningning Liu

Frontiers in cell and developmental biology 8:287 PubMed32457900

2020

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness.

Applications

Unspecified application

Species

Unspecified reactive species

Mei-Yu Quan,Qiang Guo,Jiayu Liu,Ruo Yang,Jing Bai,Wei Wang,Yaxin Cai,Rui Han,Yu-Qing Lv,Li Ding,Daniel D Billadeau,Zhenkun Lou,Saverio Bellusci,Xiaokun Li,Jin-San Zhang

Journal of neuroinflammation 17:62 PubMed32066456

2020

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Fan-Qi Kong,Shu-Jie Zhao,Peng Sun,Hao Liu,Jian Jie,Tao Xu,An-Di Xu,Ya-Qing Yang,Ye Zhu,Jian Chen,Zheng Zhou,Ding-Fei Qian,Chang-Jiang Gu,Qi Chen,Guo-Yong Yin,Han-Wen Zhang,Jin Fan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD204 antibody

Western blot - Anti-CD204 antibody (AB123946)

Immunocytochemistry/ Immunofluorescence - Anti-CD204 antibody (AB123946)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (21)

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